Results 71 to 80 of about 24,300 (246)

Telomere Dysfunction Drives Chronic Lung Allograft Dysfunction Pathology [PDF]

, 2019
ABSTRACTRationaleTelomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD) which is a major limitation to long-term survival following lung transplantation. Although shorter donor telomere lengths are associated with an increased risk of CLAD, it is unknown whether short telomeres are ...
Naikawadi, Ram P., Green, Gary, Jones, Kirk D., Achtar-Zadeh, Natalia, Mieleszko, Julia E., Kukreja, Jasleen, Greenland, John, Wolters, Paul J.   +7 more
openaire   +1 more source

Dynamic ¹⁹F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction. [PDF]

JHLT Open
Background: By the time chronic lung allograft dysfunction (CLAD), with its main phenotypes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), is diagnosed by pulmonary function testing, irreversible damage to the lung ...
Neal MA, Bos S, Holland CW, Hollingsworth KG, Meachery G, Nair A, Lordan JL, Fisher AJ, Thelwall PE.   +8 more
europepmc   +2 more sources

Hepatopulmonary syndrome as presentation of pediatric metabolic dysfunction‐associated steatohepatitis

JPGN Reports, EarlyView.
Abstract Childhood obesity is rising and leading to serious co‐morbidities, among which is metabolic dysfunction‐associated steatotic liver disease (MASLD) predisposing individuals to cirrhosis. We describe a young 11‐year‐old Hispanic male who presented with hepatopulmonary syndrome secondary to cirrhotic portal hypertension from metabolic dysfunction‐
Shruti Sakhuja, Stacey S. Beer, Kalyani R. Patel, Alexiss M. Williams, Nhu Thao Galvan, John A. Goss, Krupa R. Mysore   +6 more
wiley   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Radiological findings of complications after lung transplantation

Insights into Imaging, 2018
Complications following lung transplantation may impede allograft function and threaten patient survival. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections,
Céline Habre, Paola M. Soccal, Frédéric Triponez, John-David Aubert, Thorsten Krueger, Steve P. Martin, Joanna Gariani, Jean-Claude Pache, Frédéric Lador, Xavier Montet, Anne-Lise Hachulla   +10 more
doaj   +1 more source

Review Article: Renal Safety Profiles of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, and Entecavir for the Treatment of Chronic Hepatitis B Infection—General and Special Populations

Alimentary Pharmacology &Therapeutics, EarlyView.
Current first‐line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.
Lung‐Yi Mak, Tsung‐Hui Hu, Desmond Y. H. Yap   +2 more
wiley   +1 more source

Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation. [PDF]

, 2017
Chronic lung allograft dysfunction and its main phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), are major causes of mortality after lung transplantation (LT).
Antonietti, Jean P., Aubert, John D., Benden, Christian, Botturi, Karine, Chung, Kian,, Claustre, Johanna, Dahan, Marcel, Dromer, Claire, Fritz, Andreas, Gomez, Carine, Guillemain, Romain, Hillerdal, Gunnar,, Kessler, Romain, Knoop, Christiane, Koutsokera, Angela, Magnan, Antoine, Mal, Herve, Mornex, Jean-Francois, Mussot, Sacha, Nicod, Laurent P., Pison, Christophe, Reynaud-Gaubert, Martine L., Roux, Antoine, Royer, Pierre J., Sage, Edouard, Soccal, Paola M., Tissot, Adrien, Wewers, Mark   +27 more
core   +4 more sources

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Imaging indications and findings in evaluation of lung transplant graft dysfunction and rejection

Insights into Imaging, 2020
Lung transplantation is a treatment option in end-stage lung disease. Complications can develop along a continuum in the immediate or longer post-transplant period, including surgical and technical complications, primary graft dysfunction, rejection ...
Mnahi Bin Saeedan, Sanjay Mukhopadhyay, C. Randall Lane, Rahul D. Renapurkar   +3 more
doaj   +1 more source