Results 1 to 10 of about 82,620 (274)

Spectrum and trigger identification of hemophagocytic lymphohistiocytosis in adults: A single-center analysis of 555 cases

Frontiers in Immunology, 2022
Limited data are available about the underlying causes of hemophagocytic lymphohistiocytosis (HLH) in adults. We collected and analyzed the data of 555 cases of adult HLH.
Yi Miao, Yi Miao, Yi Miao, Jing Zhang, Jing Zhang, Jing Zhang, Qingqing Chen, Qingqing Chen, Qingqing Chen, Lingxiao Xing, Lingxiao Xing, Lingxiao Xing, Tonglu Qiu, Tonglu Qiu, Tonglu Qiu, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu, Li Wang, Li Wang, Li Wang, Lei Fan, Lei Fan, Lei Fan, Wei Xu, Wei Xu, Wei Xu, Jianyong Li, Jianyong Li, Jianyong Li, Jianyong Li   +30 more
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The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia

Frontiers in Immunology, 2022
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world with great heterogeneity. Pyroptosis has recently been recognized as an inflammatory form of programmed cell death (PCD) and shares a close relationship with apoptosis ...
Yeqin Sha, Yeqin Sha, Yeqin Sha, Rui Jiang, Rui Jiang, Rui Jiang, Yi Miao, Yi Miao, Yi Miao, Shuchao Qin, Shuchao Qin, Shuchao Qin, Wei Wu, Wei Wu, Wei Wu, Yi Xia, Yi Xia, Yi Xia, Li Wang, Li Wang, Li Wang, Lei Fan, Lei Fan, Lei Fan, Hui Jin, Hui Jin, Hui Jin, Wei Xu, Wei Xu, Wei Xu, Jianyong Li, Jianyong Li, Jianyong Li, Jianyong Li, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu   +36 more
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Targeting Bruton’s Tyrosine Kinase in CLL

Frontiers in Immunology, 2021
Targeting the B-cell receptor signaling pathway through BTK inhibition proved to be effective for the treatment of chronic lymphocytic leukemia (CLL) and other B-cell lymphomas.
Inhye E. Ahn, Jennifer R. Brown
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AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression

Frontiers in Oncology, 2021
The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions for an effective adaptive immune response.
Pablo Oppezzo, Marcelo Navarrete, Nicholas Chiorazzi   +2 more
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Monitoring and Managing BTK Inhibitor Treatment-Related Adverse Events in Clinical Practice

Frontiers in Oncology, 2021
Bruton tyrosine kinase (BTK) inhibitors represent an important therapeutic advancement for B cell malignancies. Ibrutinib, the first-in-class BTK inhibitor, is approved by the US FDA to treat patients with chronic lymphocytic leukemia (CLL)/small ...
Susan M. O’Brien, Jennifer R. Brown, John C. Byrd, Richard R. Furman, Paolo Ghia, Jeff P. Sharman, William G. Wierda   +6 more
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The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives

Frontiers in Oncology, 2023
Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard ...
Ernesto Gargiulo, Ernesto Gargiulo, Ernesto Gargiulo, Mirta Giordano, Carsten U. Niemann, Carsten U. Niemann, Etienne Moussay, Jérôme Paggetti, Pablo Elías Morande, Pablo Elías Morande   +9 more
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Case report: Identification of atypical mantle cell lymphoma with CCND3 rearrangement by next-generation sequencing

Frontiers in Oncology, 2023
The t(11;14) (q13;q32) translocation resulting in overexpression of cyclin D1 is the major oncogenic mechanism in mantle cell lymphoma (MCL). Most MCLs can be diagnosed based on morphological features, cyclin D1 expression, and IGH/CCND1 rearrangement ...
Luomengjia Dai, Luomengjia Dai, Luomengjia Dai, Han Zhang, Wen Chen, Yi Xia, Yi Xia, Yi Xia, Shuchao Qin, Shuchao Qin, Shuchao Qin, Yang Shao, Jianyong Li, Jianyong Li, Jianyong Li, Yi Miao, Yi Miao, Yi Miao, Bingzong Li, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu   +21 more
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T LYMPHOCYTE SUBSETS STUDIED IN A PATIENT WITH TWO ASSOCIATED HEMATOLOGIC NEOPLASIAS – CHRONIC LYMPHOCYTIC LEUKEMIA B AND CHRONIC MYELOID LEUKEMIA [PDF]

Romanian Journal of Medical Practice, 2019
Quantification of various cellular subpopulations facilitates the monitoring of hematological diseases, including chronic lymphocytic leukemia. Variations in the proportions of regulatory T cells in peripheral blood have been described in patients with
Georgiana Ene, Ana Maria Vlădăreanu, Horia Bumbea, Ion Dumitru   +3 more
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Determinants of Time-to-Death of Chronic Lymphocytic Leukemia Patients at Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia

Cancer Informatics, 2023
Background: Leukemia is a group of cancers that usually begin in the bone marrow and results in a large number of abnormal white blood cells. Chronic Lymphocytic Leukemia is the most prevalent leukemia in Western countries, with an estimated incidence ...
Gedam Derbew Addisia, Awoke Seyoum Tegegne, Denekew Bitew Belay, Mahider Abere Kassaw, Mitiku Wale Muluneh, Koyachew Bitew Abebe, Bezanesh Melese Masresha, Solomon Sisay Mulugeta, Setegn Muche Fentaw, Dejen Gedamu Damtie   +9 more
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Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution

Frontiers in Immunology, 2017
Efficient and accurate high-throughput DNA sequencing of the adaptive immune receptor repertoire (AIRR) is necessary to study immune diversity in healthy subjects and disease-related conditions.
Stefano Vergani, Stefano Vergani, Ilya Korsunsky, Andrea Nicola Mazzarello, Gerardo Ferrer, Nicholas Chiorazzi, Davide Bagnara, Davide Bagnara   +7 more
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