Results 1 to 10 of about 248,205 (145)

Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders [PDF]

, 2014
Chronic antigen-stimulation has been recurrently involved in the earlier stages of monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia and other B-cell chronic lymphoproliferative disorders.
Almeida, J.M.M. (Julia), Cortesão, E. (Emília), Criado, I. (Ignacio), González, M. (Marcos), Henriques, A. (Ana), Langerak, A.W. (Anton), Lecrevisse, Q. (Quentin), Nieto, W.G. (Wendy), Orfao, A. (Alberto), Paiva, A. (Artur), Rodríguez-Caballero, A. (Arancha)   +10 more
core   +4 more sources

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +1 more source

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

Nature Communications, 2018
While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences of these mutations.
Alison D. Tang, C. Soulette, M. V. van Baren, Kevyn L Hart, E. Hrabeta-Robinson, Catherine J. Wu, Angela N. Brooks   +6 more
semanticscholar   +1 more source

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia

Nature Communications, 2018
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance.
C. Herling, N. Abedpour, J. Weiss, A. Schmitt, R. Jachimowicz, O. Merkel, Maria Cartolano, S. Oberbeck, P. Mayer, Valeska Berg, Daniel Thomalla, N. Kutsch, Marius Stiefelhagen, P. Cramer, C. Wendtner, T. Persigehl, Andreas Saleh, J. Altmüller, P. Nürnberg, C. Pallasch, V. Achter, Ulrich Lang, B. Eichhorst, Roberta Castiglione, S. Schäfer, R. Büttner, K. Kreuzer, H. Reinhardt, M. Hallek, L. Frenzel, M. Peifer   +30 more
semanticscholar   +1 more source

Marked efficacy of Rituximab in multifocal motor neuropathy associated with chronic lymphocytic leukemia [PDF]

, 2016
The authors describe a patient who presented a multifocal motor neuropathy (MMN) associated with a high anti-ganglioside antibody (anti-GM1 and anti-GD1) titer at the clinical onset of a B-cell chronic lymphocytic leukemia (B-CLL). Immunomodulation (IVIg
Antonella Di, Pasquale, Antonini, Giovanni, Bucci, Elisabetta, DE SANTIS, Tiziana, Fionda, Laura, Mauro, Francesca Romana, Stefania, Morino   +6 more
core  

Multimodal Image Analysis of Chronic Leukemic Lymphoproliferative Disorders and the Hypothesis of »Single« and »Multiple« Programmed Stops in the Development of Typical and Atypical Forms of Leukemias and Lymphomas [PDF]

, 2010
The study consisted of morphometric analysis, assessment of the argyrophilic nucleolar organization region (AgNOR) characteristics, and image cytometry (ICM) in different tumor mass compartments: bone marrow (BM), peripheral blood (PB) and lymph nodes ...
Biljana Jelić Puškarić, Branimr Jakšić, Delfa Radić-Krišto, Ika Kardum-Skelin, Matko Kardum, Ozren Jakšić   +5 more
core   +2 more sources

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. [PDF]

, 1988
Recently the minor B cell subpopulation that expresses the CD5 (Leu-1) antigen has been implicated as a source of IgM autoantibodies. Chronic lymphocytic leukemia (CLL), the most common leukemia in humans, represents a malignancy of small B lymphocytes ...
Carson, DA, Chen, PP, Kipps, TJ, Tomhave, E   +3 more
core  

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

Science Translational Medicine, 2015
D. Porter, W. Hwang, N. Frey, S. Lacey, P. Shaw, A. Loren, A. Bagg, K. Marcucci, A. Shen, V. Gonzalez, David E. Ambrose, S. Grupp, A. Chew, Zhaohui Zheng, M. Milone, B. Levine, J. Melenhorst, C. June   +17 more
semanticscholar   +1 more source

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences of the United States of America, 2002

semanticscholar   +1 more source