Results 31 to 40 of about 82,620 (274)

Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study

Frontiers in Hematology
BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy
Sam Salek, Samantha Nier, Zack Pemberton-Whiteley, Tatyana Ionova, Giuseppe Ianni, Giovanni Tripepi, Nick York, Nicole Schroeter, Kathryn Huntley, Michael Rynne, Denis Costello, Lidija Pecova, Esther Natalie Oliva   +12 more
doaj   +1 more source

Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia

Haematologica, 2016
Abroad array of conditions can lead to neurological symptoms in chronic lymphocytic leukemia patients and distinguishing between clinically significant involvement of the central nervous system by chronic lymphocytic leukemia and symptoms due to other ...
Paolo Strati, Joon H. Uhm, Timothy J. Kaufmann, Chadi Nabhan, Sameer A. Parikh, Curtis A. Hanson, Kari G. Chaffee, Timothy G. Call, Tait D. Shanafelt   +8 more
doaj   +1 more source

Tensor Decomposition with Relational Constraints for Predicting Multiple Types of MicroRNA-disease Associations [PDF]

Briefings in Bioinformatics, Volume 22, Issue 3, May 2021, bbaa140, 2019
MicroRNAs (miRNAs) play crucial roles in multifarious biological processes associated with human diseases. Identifying potential miRNA-disease associations contributes to understanding the molecular mechanisms of miRNA-related diseases. Most of the existing computational methods mainly focus on predicting whether a miRNA-disease association exists or ...
arxiv   +1 more source

ALLNet: A Hybrid Convolutional Neural Network to Improve Diagnosis of Acute Lymphocytic Leukemia (ALL) in White Blood Cells [PDF]

, 2021
Due to morphological similarity at the microscopic level, making an accurate and time-sensitive distinction between blood cells affected by Acute Lymphocytic Leukemia (ALL) and their healthy counterparts calls for the usage of machine learning architectures.
arxiv   +1 more source

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Haematologica, 2018
Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease.
Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, Martina Seiffert   +15 more
doaj   +1 more source

Study of serum antioxidant levels in patients with acute lymphocytic leukemia and chronic myelocytic leukemia before and after vincristine intake [PDF]

مجلة التربية والعلم, 2012
The study included the determination of the antioxidants levels of acute lymphocytic leukemia and chronic myelocytic leukemia patients in Mosul city (Before and after taking vincristine (Chemical drug)).
Noha altaalib
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Haematologica, 2015
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target
Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic   +20 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes

Haematologica, 2015
Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Rinako Nakagawa, Milica Vukovic, Anuradha Tarafdar, Emilio Cosimo, Karen Dunn, Alison M. McCaig, Ailsa Holroyd, Fabienne McClanahan, Alan G. Ramsay, John G. Gribben, Alison M. Michie   +10 more
doaj   +1 more source