Results 221 to 230 of about 2,830,257 (398)

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Selective vulnerability of GABAergic neurons in chronic migraine. [PDF]

J Headache Pain
Hossain KH, Chuong T, Abad E, Lin J, Xia C, Li M, Chen Y, Arakaki X, Vasudevan A.   +8 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Exploratory Pain Profiling With Quantitative Sensory Testing (QST) in Episodic and Chronic Migraine. [PDF]

Eur J Pain
van Welie RF, van Welie FC, Trouerbach-Kraan JP, Dahan A, van Velzen M, Terwindt GM.   +5 more
europepmc   +1 more source

Chronic migraine [PDF]

Neurologie pro praxi, 2019
openaire   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Acromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly.
Denise Costa, Giada Giuliani, Valentina Martines, Chiara Pellicano, Valeria Mercuri, Vittorio Di Piero, Patrizia Gargiulo, Camilla Virili   +7 more
wiley   +1 more source

Recent Trends in the Pharmacological Treatment of Chronic Migraine: A Systematic Review of Randomized Controlled Trials. [PDF]

Cureus
Sharma J, Soni R, Singh S.
europepmc   +1 more source

Work Absenteeism Due to a Chronic Disease [PDF]

Research on health-related work absenteeism focuses primarily on moral hazard issues but seldom discriminates between the types of illnesses that prompt workers to stay home or seek care. This paper focuses on chronic migraine, a common and acute illness
Brouard, Marie-Ève, Lacroix, Guy
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