Results 101 to 110 of about 447,121 (304)
Epidemiological clinical characterization of patients with advanced chronic kidney disease
Acta Médica del Centro, 2016 Chronic kidney disease is considered as one of the major epidemics of the XXI century and provides a significant burden of morbidity and mortality in the world; it is important to identify and modify the factors of risk that influence its progression. In
Lexis Caridad Ramírez Felipe +3 more
doaj
BMC NephrologyBackground The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease
Liyin Chai +7 more
doaj +1 more source
Journal of the American College of Cardiology, 2000 BACKGROUND Acute deterioration in renal function is a recognized complication after coronary angiography and intervention. OBJECTIVES The goal of this study was to determine the impact on acute and long-term mortality and morbidity of contrast-induced ...
L. Gruberg +8 more
semanticscholar +1 more source
A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle
Advanced Science, EarlyView.This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin +9 more
wiley +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Association between simple renal cyst and kidney damage in a Chinese cohort study
Renal Failure, 2019 Background: The presence of simple renal cyst (SRC) has been associated to renal dysfunction, but the results were inconsistent. Accordingly, we conducted a longitudinal cohort study to explore the association between SRC and kidney damage.
Juan Chen +4 more
doaj +1 more source
Being adolescent with chronic renal failure: a view through existential phenomenology
Escola Anna Nery, 2018 Objective: To understand adolescent's experiences with chronic renal failure disease, attended in a pubic teaching hospital at São Paulo state.
Marcela Astolphi de Souza +1 more
doaj +1 more source
Renal handling of potassium in dogs with chronic renal insufficiency
Kidney International, 1981 The dynamics of potassium excretion were examined in normal dogs and dogs with chronic renal insufficiency of at least 4 weeks' duration (remnant model). All animals, in balance on diets providing 15, 50, or 100 mEq of potassium and 100 mEq of sodium, were challenged with 50 mEq of potassium chloride.
Bourgoignie, Jacques J. +4 more
openaire +2 more sources
Advanced Science, EarlyView.In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian +13 more
wiley +1 more source