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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang   +7 more
wiley   +1 more source
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Chronic Renal Insufficiency

Pediatric Clinics of North America, 1976
Among the clinical disturbances attending chronic renal disease are water and electrolyte imbalances, acidosis, anemia, the toxicity arising from retention of wastes, and growth impairment. The pathogenesis of these abnormalities is discussed along with approaches to their management.
Peter R. Lewy, John K. Hurley
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Exophthalmus in Chronic Renal Insufficiency

Scandinavian Journal of Urology and Nephrology, 1971
The present results show that exophthalmus is a common symptom in chronic renal insufficiency. Thus, contrary to the norm, 19 (67%) of 28 clinically euthyroid, chronic dialysis patients displayed increased Hertel values. Tests of thyroid function in these patients indicated a reduced thyroxine-binding capacity of the serum protein and, in some cases, a
G Prame   +3 more
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Digitalis in Chronic Renal Insufficiency

Blood Purification, 1985
Cardiac dysfunction is common in patients with terminal renal failure. However, no consensus has been reached with respect to the indications for digitalis therapy. Depression of myocardial contractility may occur as a result of circulating toxic factors, parathyroid hormone, and altered catecholaminergic responsiveness.
Eberhard Ritz, M. Rambausek
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Polyneuropathy in Chronic Renal Insufficiency

JAMA: The Journal of the American Medical Association, 1965
Peripheral neuropathy is frequently associated with chronic renal insufficiency. It presents as progressive peripheral involvement first of sensory, then motor fibers. Loss of vibration sense is the most consistent early finding. Nerve conduction measurements aid in the detection of mild or subclinical neuropathy. Patients on long-term dialysis therapy
Robert H. Jebsen   +3 more
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Calcifediol in Chronic Renal Insufficiency

JAMA: The Journal of the American Medical Association, 1976
To the Editor.— The reader who is not highly familiar with the recent developments concerning vitamin D and its various active forms may be misled by certain comments made (235: 164, 1976) by Teitelbaum and associates. First, the major reason for the interest in the treatment of renal osteodystrophy with 1,25-dihydroxycholecalciferol (1,25-dihydroxy ...
Anthony W. Norman, Jack W. Coburn
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Renal Handling of Citrate in Chronic Renal Insufficiency

Nephron, 1991
Citrate is a relevant component of the inhibitory potential of the urine environment. Its excretion and renal handling have been widely studied in subjects with normal renal function, but little is known about changes induced by chronic renal insufficiency.
Corrado Vitale   +6 more
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Cardiovascular disease in chronic renal insufficiency

American Journal of Kidney Diseases, 2000
Cardiovascular illness is an important contributor to the morbidity of kidney disease. The spectrum of cardiovascular disease (CVD) in patients with chronic renal insufficiency (CRI) includes left ventricular hypertrophy (LVH) and dilatation, ischemic heart disease, and peripheral vascular disease.
Adeera Levin, Robert N. Foley
openaire   +2 more sources

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