Results 101 to 110 of about 2,745,887 (383)

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

Optimum imaging for inverted papilloma [PDF]

, 2000
Inverted papilloma is the most common benign tumour of the nose and paranasal sinuses, and usually arises in the lateral wall of the nasal cavity and the middle meatus.
Howard, D, Lloyd, G, Lund, VJ, Savy, L
core   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Dupilumab efficacy in uncontrolled, moderate-to-severe asthma with self-reported chronic rhinosinusitis [PDF]

, 2019
BACKGROUND: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for IL-4 and IL-13 signaling, key drivers of type 2 inflammation.
Castro, Mario, et al,, Maspero, Jorge F
core   +1 more source

Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis [PDF]

, 2006
OBJECTIVE: To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis (CRS) for response to endoscopic sinus surgery (ESS).
Bhattacharyya N., Damm M, Dhong HJ, Drvi P, Dunlop G, Kaliner MA, Kalogjera L, Lavigne F, Marks SC, Watelet JB   +9 more
core   +1 more source

Cost burden and resource utilization in patients with chronic rhinosinusitis and nasal polyps

The Laryngoscope, 2019
Establish treatment patterns and economic burden in US patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) versus without chronic rhinosinusitis (CRS). Determine comparative costs of subgroups with high clinical burden.
N. Bhattacharyya, Sara Villeneuve, V. Joish, C. Amand, L. Mannent, N. Amin, P. Rowe, J. Maroni, L. Eckert, Tony Yang, Asif H Khan   +10 more
semanticscholar   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Establishment of FTS⁃based health education path for chronic rhinosinusits patients in perioperative period

Huli yanjiu, 2020
ObjectiveTo develop a FTS⁃based health education path for chronic rhinosinusitis patients in perioperative period，so as to facilitate clinical nurses to provide systematic and comprehensive health education for chronic rhinosinusitis patients in ...
LI Chenjiao, WANG Binquan
doaj  

Dupilumab reduces local type 2 pro‐inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2‐mediated inflammatory disease associated with significant clinical, social, and economic burdens and high unmet therapeutic need.
Karin Jonstam, B. Swanson, L. Mannent, L. Cardell, N. Tian, Ying Wang, Donghui Zhang, C. Fan, G. Holtappels, J. Hamilton, Annette Grabher, N. Graham, G. Pirozzi, C. Bachert   +13 more
semanticscholar   +1 more source

Real‐life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient‐reported outcomes by mobile technology offers the possibility to better understand real‐life burden of ...
S. Seys, Shana De Bont, W. Fokkens, C. Bachert, I. Alobid, M. Bernal-Sprekelsen, L. Bjermer, I. Callebaut, L. Cardell, S. Carrie, P. Castelnuovo, R. Cathcart, J. Constantinidis, L. Cools, M. Cornet, G. Clement, T. Cox, L. Delsupehe, J. Correia-de-Sousa, L. Deneyer, G. De Vos, Z. Diamant, M. Doulaptsi, S. Gane, P. Gevaert, C. Hopkins, V. Hox, T. Hummel, W. Hosemann, R. Jacobs, M. Jorissen, A. Kjeldsen, B. Landis, W. Lemmens, A. Leunig, V. Lund, G. Mariën, J. Mullol, M. Onerci, S. Palkonen, I. Proano, E. Prokopakis, D. Ryan, H. Riechelmann, P. Sahlstrand-Johnson, Sanna Salmi-Toppila, C. Segboer, K. Speleman, A. Steinsvik, P. Surda, P. Tomazic, O. Vanderveken, L. Van Gerven, T. Van Zele, J. Verfaillie, B. Verhaeghe, K. Vierstraete, S. Vlaminck, M. Wagenmann, B. Pugin, P. Hellings   +60 more
semanticscholar   +1 more source