Results 11 to 20 of about 2,745,887 (383)

EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023.

Rhinology, 2023
Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a significant impact on the quality of life (QoL). It is typically characterized by a type 2 inflammatory reaction and by comorbidities such as asthma, allergies and ...
W. Fokkens, A. Viskens, Vibeke Backer, D. Conti, E. Corso, P. Gevaert, G. Scadding, Martin Wagemann, M. B. Sprekelsen, A. Chaker, E. Heffler, Joseph K. Han, E. V. Staeyen, C. Hopkins, J. Mullol, A. Peters, S. Reitsma, B. Senior, P. Hellings   +18 more
semanticscholar   +1 more source

Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real‐life study (DUPIREAL)

Allergy. European Journal of Allergy and Clinical Immunology, 2023
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health‐related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, although real‐world evidence ...
E. de Corso, E. Pasquini, M. Trimarchi, I. La Mantia, F. Pagella, G. Ottaviano, M. Garzaro, C. Pipolo, S. Torretta, V. Seccia, Elena Cantone, A. Ciofalo, D. Lucidi, G. Fadda, P. Pafundi, S. Settimi, C. Montuori, F. Anastasi, G. Pagliuca, A. Ghidini, C. Cavaliere, M. Maffei, F. Bussu, S. Gallo, Frank Rikky Mauritz Canevari, G. Paludetti, J. Galli   +26 more
semanticscholar   +1 more source

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Clinical Otolaryngology, 2023
To investigate the association between laryngopharyngeal reflux (LPR), gastroesophageal reflux disease (GERD) and recalcitrant chronic rhinosinusitis (CRS).
J. Lechien, S. Saussez, C. Hopkins
semanticscholar   +1 more source

Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps

Journal of Asthma and Allergy, 2021
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high
C. Bachert, N. Bhattacharyya, M. Desrosiers, Asif H Khan   +3 more
semanticscholar   +1 more source

The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps

International Forum of Allergy and Rhinology, 2022
Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally associated with eosinophilic tissue infiltration linked to type 2 inflammation and characterized by elevated levels of interleukin (IL)‐5 and other type 2 inflammatory mediators.
P. Gevaert, Joseph K. Han, Steven G. Smith, A. Sousa, P. Howarth, S. Yancey, R. Chan, C. Bachert   +7 more
semanticscholar   +1 more source

Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant morbidity and costs to our health system. The study of CRS has progressed from an era focused on phenotype to include endotype‐based information.
A. Kato, Anju T Peters, W. Stevens, R. Schleimer, B. Tan, R. Kern   +5 more
semanticscholar   +1 more source

The EUFOREA pocket guide for chronic rhinosinusitis.

Rhinology, 2022
Chronic rhinosinusitis (CRS) is known to affect around 5 % of the total population, with major impact on the quality of life of those severely affected (1).
P. Hellings, W. Fokkens, R. Orlandi, G. F. Adriaensen, I. Alobid, F. Baroody, L. Bjermer, B. Senior, A. Cervin, N. Cohen, J. Constantinidis, E. De Corso, M. Desrosiers, Z. Diamant, R. Douglas, S. Gane, P. Gevaert, J. Han, R. Harvey, C. Hopkins, R. Kern, B. Landis, J. T. Lee, A. Leunig, V. Lund, B. Manuel-Sprekelsen, J. Mullol, C. Philpott, E. Prokopakis, S. Reitsma, D. Ryan, S. Salmi, G. Scadding, R. Schlosser, A. Steinsvik, P. Tomazic, E. Van Staeyen, T. Van Zele, O. Vanderveken, A. Viskens, D. Conti, M. Wagenmann   +41 more
semanticscholar   +1 more source

Environmental air pollution and chronic rhinosinusitis: A systematic review

Laryngoscope Investigative Otolaryngology, 2022
Chronic rhinosinusitis (CRS) is a highly prevalent and burdensome disease. The pathophysiology is not fully elucidated, but environmental pollutants have been suggested to impact the inflammatory component of the disease process.
E. M. Leland, V. Vohra, Stella M. Seal, Zhenyu Zhang, Murugappan Ramanathan   +4 more
semanticscholar   +1 more source

Impact of rhinosinusal polyposis on CT score in patients with chronic rhinosinustis [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. Chronic sinusitis is a disease characterized with mucosal inflammatoion of nasal and paranasal sinuses for at least 12 weeks. In order to assess the extent and severity of inflammatory changes in paranasal sinuses CT score according to ...
Dudvarski Zoran, Janošević Ljiljana, Penđer Ivica, Đukić Vojko, Ješić Snežana, Dimitrijević Milovan, Arsović Nenad   +6 more
doaj   +1 more source

Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine

Children, 2023
Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory ...
Iva Mrkić Kobal, Mirjana Turkalj, Davor Plavec   +2 more
doaj   +1 more source