Results 21 to 30 of about 5,345,179 (257)
Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Chronic Stress, 2020 Background Ketamine is a novel fast-acting antidepressant. Acute ketamine treatment can reverse microstructure deficits and normalize functional alterations in the brain, but little is known about the impacts of ketamine on brain volumes in individuals ...
Dan Dai +7 more
doaj +1 more source
Stress and neurochemical changes associated with chronic alcohol administration [PDF]
, 2001 : There is considerable recent experimental evidence that suggests that stress plays a major role in the development of dependence on drugs of abuse, but the potential mechanisms involved are not yet fully understood.
O'Callaghan, Matthew Joseph
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
FoodsAs a widely available dietary supplement, γ-Aminobutyric acid (GABA) exhibits potential for early intervention against Alzheimer’s disease (AD). This study demonstrates that GABA alleviates AD neuroinflammation, and its suppression of astrocytic pro ...
Jingzhu Zhang +5 more
doaj +1 more source
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source
Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids
Pediatric Blood &Cancer, EarlyView.ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz +12 more
wiley +1 more source
Communications BiologyOccupational crystalline silica (CS) particle exposure leads to silicosis. The burden of CS-associated disease remains high, and treatment options are limited due to vague mechanisms.
Yichuan You +8 more
doaj +1 more source
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective
Chronic Stress, 2020 Genome-wide association studies (GWAS) have been performed for many psychiatric disorders and revealed a complex polygenic architecture linking mental and physical health phenotypes.
Frank R. Wendt +4 more
doaj +1 more source
Anhedonia in the shadow of chronic social defeat stress, or When the experimental context matters [PDF]
, 2008 One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events,
Dmitry A. Smagin +4 more
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Development and psychometric validation of the chronic life stress questionnaire : a multidomain measure of chronic stress exposure [PDF]
, 2022 Chronic life stress—ongoing, non-acute strain—is implicated in physical and psychiatric disease pathways, including depression, but is understudied. Critically, the absence of psychometrically sound, valid, and efficient measures for comprehensively ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
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