Results 121 to 130 of about 216,838 (262)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

COMPARATIVE CHARACTERISTICS OF THE STRUCTURE OF THE VENOUS WALL OF THE EXTREMITIES OF HUMANS AND DOGS

Медицина в Кузбассе
The study of the causes and mechanisms of development of varicose veins of the lower extremities does not lose its relevance. Most often, Wistar rats are used in experiments for morphological studies of the venous system of the lower extremities. However,
Дмитрий Алексеевич Евсюков, Антон Юрьевич Цуканов, Юрий Тихонович Цуканов, Вера Павловна Дорофеева, Илья Олегович Снитко, Мурат Ханапиевич Аликберов, Александр Николаевич Кузовкин, Илья Евгеньевич Винник   +7 more
doaj  

Porto-Sinusoidal Vascular Disorder-Spectrum Portal Venopathy as a Structural Substrate for Portal Hypertension in Anti-Centromere Antibody-Positive Primary Biliary Cholangitis. [PDF]

Pathol Int
Ando Y, Mabuchi S, Nakayama S, Honda A, Hokari R, Harada K, Murashima N.   +6 more
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

The national acceptance of pelvic congestion syndrome among other common venous pathologies. [PDF]

J Vasc Surg Venous Lymphat Disord
Gupta A, Conroy PD, Dehaven C, Puli A, Judelson D, Lombardi JV, Hastings L, McMackin K.   +7 more
europepmc   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Endovascular Treatment of Hemoptysis: Does Bronchial Artery Embolization Fit All? [PDF]

Diagnostics (Basel)
Bertuccio FR, Pisanu L, Accordino G, Bosio M, Quaretti P, Cionfoli N, Corti R, D'Agostino MA, Stella GM, Corsico AG, Cascina A.   +10 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Outcomes of endovenous laser ablation in patients with incompetent Giacomini vein. [PDF]

J Vasc Surg Venous Lymphat Disord
Babić S, Milačić A, Slović B, Zekić P, Debeljak M, Ratković P, Gajin P, Matić P.   +7 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source