Results 191 to 200 of about 216,838 (262)

Liver and Spleen Stiffness as Non-Invasive Tools Assessing Liver Congestion in Patients With Budd-Chiari Syndrome. [PDF]

Liver Int
Fodor A, Thompson MA, Nicoara-Farcau O, Belmonte E, Garcia-Criado Á, Darnell A, Pérez-Campuzano V, Vizcarra P, Requejo I, Falga Á, Veléz M, Fernandez I, Sueiras A, Torres S, Gazda J, Baiges A, Shalaby S, Ojeda A, Martin DS, Procopet B, Hernández-Gea V, Turon F, García-Pagan JC.   +22 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Exploring causal relationships between circulating inflammatory proteins and superficial thrombophlebitis: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu Q, Chen W, Zhang Y, Wang X, Mao H, Chen B, Xu J, Wang Y.   +7 more
europepmc   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

IgG4-Related Hepatic Inflammatory Pseudotumor With Extensive Portal Vein Thrombosis Mimicking Hepatocellular Carcinoma. [PDF]

ACG Case Rep J
Abouzeid M, Baratelli F, Mythri M.
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Aspiration-Assisted Catheter-Directed Foam Sclerotherapy Using the Sclerosafe Device for Anterior Saphenous Vein Insufficiency: A Retrospective Study. [PDF]

Healthcare (Basel)
Stanišić MG, Czajkowski K, Borecka-Sobczak J, Markiewicz S, Snoch-Ziołkiewicz M, Błaszak J, Tomczak J.   +6 more
europepmc   +1 more source

Isolated Pulmonary Vein Stenosis Mimicking Chronic Lung Disease

The Internet Journal of Pediatrics and Neonatology, 2004
openaire   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source