Results 141 to 150 of about 98,391 (335)

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Outcomes and Associated Factors of Open Surgical Treatment in Patients with Chronic Venous Insufficiency Related to Primary Varicose Veins: Findings from Jakaya Kikwete Cardiac Institute, Tanzania [PDF]

Christine Hyasint Paul, Vulstan James Shedura, Evarist Nyawawa, Ally Mwanga, Moses Byomuganyizi   +4 more
openalex   +1 more source

PC206. Analyses of Gene Expression and Mechanisms of Post-Transcriptional Gene Expression Modification(s) in Metabolic Pathways of Chronic Venous Insufficiency [PDF]

, 2015
Cynthia K. Shortell, Jovan N. Markovic
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Analysis of Venous Insufficiency Risk Factors and Demographic Characteristics among Nurses: An Analytical Cross-Sectional Study

Medicina
Background and Objectives: Chronic venous insufficiency negatively affects the quality of life and reduces the job performance of nurses, who are important components of the healthcare system.
Sevcan Avcı Işık, Elif Budak Ertürk, Hakkı Tankut Akay, Azize Karahan, Denizhan Akpınar, Arif Okay Karslıoğlu   +5 more
doaj   +1 more source

Clinical presentation and associated factors of lower limb chronic venous insufficiency at a tertiary hospital in Uganda: a cross-sectional study. [PDF]

, 2022
Elizabeth Komurembe, Wilberforce Kabweru, Peter Majeme, Robert Odongo, John Paul Magala   +4 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Correlation of venous clinical severity score and venous disability score with dermatology life quality index in chronic venous insufficiency

, 2020
Tanusree Sarkar, Subhadeep Mallick, Tirthankar Gayen, Biswanath Naskar, Adrija Datta, Somenath Sarkar   +5 more
openalex   +1 more source

Pilot study on the effect of grape seed proanthocyanidin extract on inferior vene cava blood flow in patients with chronic venous insufficiency using 4D flow MRI

, 2022
Hyuk Jae Jung, Ki Seok Choo
openalex   +1 more source

DNA‐Inspired Multi‐Functional Double‐Cross‐Linking Self‐Healing Hydrogel Promotes the Healing of Diabetic Wounds

Advanced Science, EarlyView.
A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang, Yue Hu, Yikun Ju, Naihsin Hsiung, Juyi Ye, Anquan Jian, Lanjie Lei, Bairong Fang   +7 more
wiley   +1 more source