Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng+5 more
wiley +1 more source
A 903-year annual temperature reconstruction for the southeastern tibetan plateau from the tree ring widths of Juniperus saltuaria. [PDF]
Xu S+6 more
europepmc +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang+7 more
wiley +1 more source
Losing half the crown hardly affects the stem growth of a xeric southern beech population. [PDF]
Reiter EJ, Weigel R, Leuschner C.
europepmc +1 more source
Acoustic features are independently associated with heart failure and pulmonary hypertension
Abstract Introduction Acoustic analysis of speech has discriminated decompensated acute heart failure (HF). Speech rate (SR) and cepstral peak prominence (CPP) variation are among features previously evaluated. However, the association between SR and CPP and chronic stable HF with and without pulmonary hypertension (PH) as well as PH alone have not ...
Jaskanwal Deep S. Sara+6 more
wiley +1 more source
Open Access Dataset and Common Data Model for Pulse Oximeter Performance Data. [PDF]
Fong N+26 more
europepmc +1 more source
Comorbidity trajectories before and after the diagnosis of heart failure: A UK Biobank cohort study
Time of diagnosis of comorbidities in relation to heart failure. COPD, chronic obstructive pulmonary disease; MI, myocardial infarction. Abstract Aims Heart failure (HF) is frequently associated with multiple comorbidities. We aimed to define their trajectory of accrual to identify opportunities for disease prevention. Methods and results We identified
Hugo MacGowan+12 more
wiley +1 more source
Central Asia Cold Case: Siberian Pine Fingers New Suspects in Growth Decline CA 1700 CE. [PDF]
Meko DM+6 more
europepmc +1 more source
Debating Lapita: distribution, chronology, society and subsistence [PDF]
Bedford, S.+5 more
core +2 more sources
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard+29 more
wiley +1 more source