Results 121 to 130 of about 322,306 (203)

Activation and inhibition of Notch signaling facilitate proliferative regeneration of sensory cells in adult mice

Eye &ENT Research, EarlyView.
Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng, Tao Jiang, Zhengyi Chen, Huawei Li, Luo Guo, Wenyan Li   +5 more
wiley   +1 more source

A 903-year annual temperature reconstruction for the southeastern tibetan plateau from the tree ring widths of Juniperus saltuaria. [PDF]

Sci Rep
Xu S, Zheng C, Shang Z, Zhang Z, Kong X, Robertson I, Zhao Z.   +6 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Losing half the crown hardly affects the stem growth of a xeric southern beech population. [PDF]

Sci Rep
Reiter EJ, Weigel R, Leuschner C.
europepmc   +1 more source

Acoustic features are independently associated with heart failure and pulmonary hypertension

ESC Heart Failure, EarlyView.
Abstract Introduction Acoustic analysis of speech has discriminated decompensated acute heart failure (HF). Speech rate (SR) and cepstral peak prominence (CPP) variation are among features previously evaluated. However, the association between SR and CPP and chronic stable HF with and without pulmonary hypertension (PH) as well as PH alone have not ...
Jaskanwal Deep S. Sara, Keiko Ishikawa, Yan Li, D.M. Anisuzzaman, Lilach O. Lerman, Amir Lerman, Diana Orbelo   +6 more
wiley   +1 more source

Open Access Dataset and Common Data Model for Pulse Oximeter Performance Data. [PDF]

Sci Data
Fong N, Lipnick MS, Behnke E, Chou Y, Elmankabadi S, Ortiz L, Almond CS, Auchus I, Burnett GW, Bisegerwa R, Conrad DR, Hendrickson CM, Hooli S, Kopotic R, Leeb G, Martin D, McCollum ED, Monk EP, Moore KL, Shmuylovich L, Scott JB, Wong AI, Zhou T, Pirracchio R, Bickler PE, Feiner J, Law TJ.   +26 more
europepmc   +1 more source

Comorbidity trajectories before and after the diagnosis of heart failure: A UK Biobank cohort study

European Journal of Heart Failure, EarlyView.
Time of diagnosis of comorbidities in relation to heart failure. COPD, chronic obstructive pulmonary disease; MI, myocardial infarction. Abstract Aims Heart failure (HF) is frequently associated with multiple comorbidities. We aimed to define their trajectory of accrual to identify opportunities for disease prevention. Methods and results We identified
Hugo MacGowan, Oliver I. Brown, Michael Drozd, Andrew M.N. Walker, Marilena Giannoudi, Sam Straw, Maria F. Paton, John Gierula, Melanie McGinlay, Kathryn J. Griffin, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon   +12 more
wiley   +1 more source

Central Asia Cold Case: Siberian Pine Fingers New Suspects in Growth Decline CA 1700 CE. [PDF]

Plants (Basel)
Meko DM, Zhirnova DF, Belokopytova LV, Kholdaenko YA, Babushkina EA, Mapitov NB, Vaganov EA.   +6 more
europepmc   +1 more source

Debating Lapita: distribution, chronology, society and subsistence [PDF]

, 2019
Bedford, S., Burley, D., Sand, C., Sheppard, P., Spriggs, M., Summerhayes, G.   +5 more
core   +2 more sources

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source