Results 71 to 80 of about 383,237 (301)
Advanced Science, EarlyView.The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei +18 more
wiley +1 more source
PAIGE: Chronologies for Polar Paleoclimate Archives – Kickoff conference of a new Italian–German partnership project [PDF]
, 2022 openalex +1 more source
Advanced Science, EarlyView.Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng +4 more
wiley +1 more source
Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Advanced Science, EarlyView.This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin +3 more
wiley +1 more source
Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention
Advanced Science, EarlyView.This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi +14 more
wiley +1 more source
Prachi Prajna, 2020 Which text contains the earliest attestation of the use of technology to harness Sun's energy to light a fire? Is there an implication of translating kaṃsaḥ as white copper for the global history of metallurgy? Which is the oldest attestation of at least
Megh Kalyanasundaram
doaj
Re–Os and Sr Isotopic Study of Permian–Triassic Sedimentary Rocks from the Himalaya: Shale Chronology and Carbonate Diagenesis [PDF]
, 2021 Anirban Mandal +5 more
openalex +1 more source
Advanced Science, EarlyView.Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye +12 more
wiley +1 more source
Autonomous Polymer Frameworks for Sustainable Tissue‐Interfaced Plastic Bioelectronics
Advanced Science, EarlyView.This review focuses on plastic bioelectronic systems integrated with autonomous polymer frameworks (auto‐POFs) and summarizes recent progress in this field. It provides an in‐depth analysis of the design strategies and operational mechanisms of auto‐POFs, highlighting their pivotal role in enhancing the sustainability and interfacial adaptability of ...
Elvis K. Boahen +8 more
wiley +1 more source
Mapping the Z-Axis: Early Archaeological Engagement with Time and Space in the Ancient Near East
Bulletin of the History of Archaeology, 2014 The development of the archaeology of the ancient Near East as an independent discipline in the nineteenth century, with its focus on uncovering the peoples and places of the past, particularly from the biblical world, contributed to a visual tradition ...
Susan Cohen
doaj +1 more source