Results 51 to 60 of about 4,252 (243)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Classic motor chunking theory fails to account for behavioural diversity and speed in a complex naturalistic task.

PLoS ONE, 2019
In tasks that demand rapid performance, actions must be executed as efficiently as possible. Theories of expert motor performance such as the motor chunking framework suggest that efficiency is supported by automatization, where many serial actions are ...
Joseph J Thompson, Caitlyn M McColeman, Mark R Blair, Andrew J Henrey   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions

Frontiers in Computational Neuroscience, 2017
The striatum is the primary input nucleus for the basal ganglia, and receives glutamatergic afferents from the cortex. Under the hypothesis that basal ganglia perform action selection, these cortical afferents encode potential “action requests.” Previous
David Buxton, Enrico Bracci, Paul G. Overton, Kevin Gurney   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Perceptual chunking and its effect on memory in speech processing: ERP and behavioral evidence.

Frontiers in Psychology, 2014
We examined how perceptual chunks of varying size in utterances can influence immediate memory of heard items (monosyllabic words). Using behavioral measures and ERPs (N400) we evaluated the quality of the memory trace for targets taken from perceived ...
Annie C. Gilbert, Annie C. Gilbert, Victor J. Boucher, Boutheina eJemel, Boutheina eJemel   +4 more
doaj   +1 more source

Discourse chunking [PDF]

Proceedings of the 41st Annual Meeting on Association for Computational Linguistics - ACL '03, 2003
Discourse chunking is a simple way to segment dialogues according to how dialogue participants raise topics and negotiate them. This paper explains a method for arranging dialogues into chunks, and also shows how discourse chunking can be used to improve performance for a dialogue act tagger that uses a case-based reasoning approach.
openaire   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Cognitive processing in new and practiced discrete keying sequences

Frontiers in Psychology, 2010
This study addresses the role of cognitive control in the initiation and execution of familiar and unfamiliar movement sequences. To become familiar with two movement sequences participants first practiced two discrete key press sequences by responding ...
Willem B Verwey, Elger L Abrahamse, Elian De Kleine   +2 more
doaj   +1 more source