Advanced Science, EarlyView.This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang +9 more
wiley +1 more source
Enrollment patterns among medicaid beneficiaries with sickle cell disease: Multistate findings from the sickle cell data collection program. [PDF]
PLoS OneSingh A +9 more
europepmc +1 more source
Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su +14 more
wiley +1 more source
Social ties in old age: the effect of the COVID-19 pandemic. [PDF]
Eur J AgeingMenashe-Oren A, Uccheddu D, Rizzi EL.
europepmc +1 more source
Research on gearbox temperature field image fault diagnosis method based on transfer learning and deep belief network. [PDF]
Sci Rep, 2023 Lu X, Li P.
europepmc +1 more source
Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis
Advanced Science, EarlyView.Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang +7 more
wiley +1 more source
Ultrafast synthesis of α-aminophosphonates using ternary deep eutectic solvent in water. [PDF]
Sci RepAzizi N +3 more
europepmc +1 more source
Sleep Alters the Velocity of Physiological Brain Pulsations in Humans
Advanced Science, EarlyView.Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy +13 more
wiley +1 more source
Coverage Disruptions and Transitions Across the ACA's Medicaid/Marketplace Income Cutoff. [PDF]
J Gen Intern Med, 2022 Goldman AL, Gordon SH.
europepmc +1 more source
Advanced Science, EarlyView.A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu +7 more
wiley +1 more source