Results 161 to 170 of about 13,285 (279)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

New York's Basic Health Program Increased Subsidized Insurance Coverage From Preconception To The Postpartum Period. [PDF]

Health Aff (Millwood)
Eddelbuettel JCP, Daw JR, Galbraith AA, Gordon SH, Kaimal A, Garabedian LF.   +5 more
europepmc   +1 more source

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract. [PDF]

Sci Robot, 2022
Srinivasan SS, Alshareef A, Hwang AV, Kang Z, Kuosmanen J, Ishida K, Jenkins J, Liu S, Madani WAM, Lennerz J, Hayward A, Morimoto J, Fitzgerald N, Langer R, Traverso G.   +14 more
europepmc   +1 more source

Quiet Clean Short-haul Experimental Engine (QCSEE) main reduction gears detailed design report [PDF]

Lightweight turbine engines with geared slower speed fans are considered. The design of two similar but different gear ratio, minimum weight, epicyclic star configuration main reduction gears for the under the wing (UTW) and over the wing (OTW) engines ...
Defeo, A., Kulina, M.
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Free surface oscillation driven by rotating stirrer. [PDF]

Eur Phys J E Soft Matter
Watamura T, Iwata R, Sugiyama K.
europepmc   +1 more source

Job creation and job destruction in a regulated labor market: The case of Austria [PDF]

We study Austrian job reallocation in the period of 1978 to 1998, using a large administrative dataset where we correct for "spurious" entries and exits of firms.
Alfred M Stiglbauer, Florian Stahl, Josef Zweim�ller, Rudolf Winter-Ebmer   +3 more
core  

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source

Understanding the Risks and Benefits of Implementing AI-Enabled Remote Patient Monitoring Systems for Disease Management. [PDF]

Int J Environ Res Public Health
Nabi J, Staynings R, Sofi JI, Willis HH.
europepmc   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source