Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Advanced Science, EarlyView.FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu +6 more
wiley +1 more source
Understanding the effect of adverse childhood experiences on the risk of engaging in physical violence toward an intimate partner: The influence of relationship, social psychological, and sociodemographic contextual risk factors. [PDF]
Child Abuse Negl, 2023 Kaufman-Parks AM +3 more
europepmc +1 more source
Reassessing Labor Market Reforms: Temporary Contracts as a Screening Device [PDF]
Standard models of temporary contracts are either inconclusive, or fail to account for the positive correlation between temporary contracts and the employment rate, and for the high transition rates into permanent employment measured in Europe.
Renato Faccini
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Introduction to Data Ethics [PDF]
, 2018 An Introduction to data ethics, focusing on questions of privacy and personal identity in the economic world as it is defined by big data technologies, artificial intelligence, and algorithmic capitalism. Originally published in The
Brusseau, James
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The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Test study on the effect of lubricants on E-axle power loss
Jixie chuandongObjectiveThe typical input speed of the electric drive axle is 12 000-22 000 r/min, but the existing research work basically focuses on the gearbox, drive axle and other gear transmission devices used in traditional internal combustion engines.
LIU Hongwei +5 more
doaj
Sheep's Butter and Correspondent Buttermilk Produced with Sweet Cream and Cream Fermented by Aromatic Starter, Kefir and Probiotic Culture. [PDF]
Foods, 2023 Silva T +7 more
europepmc +1 more source
Evaluation of a series hybrid thrust bearing at DN values to three million. 2: Fabrication and testing [PDF]
Results of tests made to determine the experimental performance of a series hybrid bearing are reported. The bearing consists of a 150 mm ball bearing and a centrifugally actuated, conical, fluid film bearing fitting an envelope with an outer radius of ...
Eusepi, M., Winn, L. W.
core +1 more source
Seeking Alpha: Excess Risk Taking and Competition for Managerial Talent [PDF]
, 2011 We present a model of labor market equilibrium in which managers are risk- averse, managerial talent (\alpha") is scarce, and rms seek alpha, that is, compete for this talent.
Acharya, Viral V. +2 more
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