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Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity

Atherosclerosis, 2012
To better understand the postprandial clearance of triglyceride-rich lipoproteins (TRLs) and its relation to the fasting kinetics of TRLs.Two studies were performed on 30 male subjects: a fasting kinetic study to determine the fasting secretion and clearance rates of apolipoprotein B (apoB) 100 and triglycerides in the very low-density lipoprotein 1 ...
Jukka Westerbacka   +7 more
openaire   +4 more sources

Regulation of chylomicron production in humans

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Chylomicrons (CM), secreted by the intestine in response to fat ingestion and to a lesser extent during the postabsorptive state (lipid poor CM), are the major vehicles whereby ingested lipids are transported to and partitioned in energy-storing and energy-utilizing tissues of the body.
Changting Xiao, Gary F. Lewis
openaire   +3 more sources

Chylomicron retention disease: genetics, biochemistry, and clinical spectrum

Current Opinion in Lipidology, 2019
Purpose of review Chylomicron retention disease (CRD) is an autosomic recessive disorder, in which intestinal fat malabsorption is the main cause of diverse severe manifestations.
E. Levy, P. Poinsot, S. Spahis
semanticscholar   +1 more source

Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis.

Current Opinion in Lipidology, 2019
PURPOSE OF REVIEW In this review, we describe novel findings related to intestinal lipid transport in lymphatic vessels. RECENT FINDINGS Studies have shown that chylomicron entry to lacteals and lymph movement in intestinal lymphatic capillaries is an ...
K. Hokkanen   +2 more
semanticscholar   +1 more source

Chylomicron and chylomicron remnant catabolism

Current Opinion in Lipidology, 1991
Hepatic clearance of chylomicrons and chylomicron remnants appears to involve several steps: sequestration in the space of Disse, further lipolytic processing, and receptor-mediated internalization and degradation. The low-density lipoprotein receptor and possibly the low-density lipoprotein receptor-related protein may participate in this process ...
Robert W. Mahley, M. Mahmood Hussain
openaire   +2 more sources

Effects of VLDL, chylomicrons, and chylomicron remnants on platelet aggregability

Thrombosis Research, 1995
Although influences of cholesterol-rich lipoproteins on platelet aggregation are well established, the knowledge of interactions between triglyceride-rich lipoproteins and platelets, in particular in the postprandial state, is limited and controversial.
Orth, Matthias   +2 more
openaire   +4 more sources

New Insights into the Regulation of Chylomicron Production.

Annual review of nutrition, 2015
Dietary lipids are efficiently absorbed by the small intestine, incorporated into triglyceride-rich lipoproteins (chylomicrons), and transported in the circulation to various tissues. Intestinal lipid absorption and mobilization and chylomicron synthesis
Satya Dash   +3 more
semanticscholar   +1 more source

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