Results 91 to 100 of about 55,260 (216)

Genetic Variation in ADHD‐Related Risk Genes in an Indigenous Population of the Amazon

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Attention‐Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder; however, its genetic architecture remains poorly explored in Indigenous populations. This study aimed to analyze and characterize genetic variation in 11 genes (ADGRL3, CDH8, DCC, DUSP6, FOXP1, FOXP2, MEF2C, PCDH7, SEMA6D, SORCS3, and ST3GAL3 ...
Hirlesson Paixão de Matos, Natasha Monte, Kaio Evandro Cardoso Aguiar, Rita de Cássia Calderaro, Aline Pasquini Santos, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐Dos‐Santos, Sandro José De Souza, Ândrea Ribeiro‐Dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista Dos Santos, Ney Pereira Carneiro Dos Santos   +11 more
wiley   +1 more source

Age Is an Effect Modifier of Thrombectomy Benefit in a Socioeconomically Vulnerable Stroke Population

Annals of Neurology, EarlyView.
Objective Randomized trials from high‐income countries have shown that endovascular treatment (EVT) yields similar benefits in elderly and non‐elderly patients with large vessel occlusion stroke (LVOS). However, evidence from low/middle‐income countries remains scarce.
Fabricio O. Lima, Francisco José de A. Mont'Alverne, Letícia C. Rebello, Daniel G. Abud, Gisele S. Silva, Michel E. Frudit, Mário B. Wagner, Jamary Oliveira‐Filho, Diogo C. Haussen, David S. Liebeskind, Octávio M. Pontes‐Neto, Norberto A.F. Frota, Guilherme Dabus, Gabriel R. de Freitas, Adson F. de Lucena, Jeffrey L. Saver, Raul G. Nogueira, Sheila C.O. Martins, for the RESILIENT Trial Investigators   +18 more
wiley   +1 more source

Indigenous Peoples and local communities report ongoing and widespread climate change impacts on local social-ecological systems

Communications Earth & Environment
The effects of climate change depend on specific local circumstances, posing a challenge for worldwide research to comprehensively encompass the diverse impacts on various local social-ecological systems. Here we use a place-specific but cross-culturally
Victoria Reyes-García, David García-del-Amo, Santiago Álvarez-Fernández, Petra Benyei, Laura Calvet-Mir, André B. Junqueira, Vanesse Labeyrie, Xiaoyue LI, Sara Miñarro, Vincent Porcher, Anna Porcuna-Ferrer, Anna Schlingmann, Christoph Schunko, Ramin Soleymani, Adrien Tofighi-Niaki, Mariam Abazeri, Emmanuel M. N. A. N. Attoh, Ayansina Ayanlade, Julia Vieira Da Cunha Ávila, Daniel Babai, Rodrigo C. Bulamah, Joao Campos-Silva, Rosario Carmona, Julián Caviedes, Rumbidzayi Chakauya, Mouna Chambon, Zhuo Chen, Fasco Chengula, Esther Conde, Aida Cuní-Sanchez, Christophe Demichelis, Evgeniya Dudina, Álvaro Fernández-Llamazares, Eranga K. Galappaththi, Claudia Geffner-Fuenmayor, Drew Gerkey, Marcos Glauser, Eric Hirsch, Tomás Huanca, José Tomás Ibarra, Andrea E. Izquierdo, Leneisja Junsberg, Marisa Lanker, Yolanda López-Maldonado, Juliette Mariel, Giulia Mattalia, Mohamed D. Miara, Miquel Torrents-Ticó, Maedeh Salimi, Aibek Samakov, Reinmar Seidler, Victoria Sharakhmatova, Uttam Babu Shrestha, Alpy Sharma, Priyatma Singh, Tungalag Ulambayar, Rihan Wu, Ibrahim S. Zakari   +57 more
doaj   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Pracaxi Oil as a Potential Inhibitor of Fat Bloom

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Fat bloom is one of the major technological challenges faced by the chocolate industry, caused by the polymorphic transition from β2(V) to β1(VI) crystals in cocoa butter (CB). One strategy to slow down this polymorphic transition is the addition of lipids rich in very long chain fatty acids (VLCFA), such as behenic acid.
Victoria Marques Gropelli, Priscila Dayane De Freitas Santos, Thayná Torres Da Silva, Ana Paula Badan Ribeiro, Rosiane Lopes Cunha   +4 more
wiley   +1 more source

Alkali‐Catalyzed Synthesis of Acylglycerol Estolides Exclusively from Castor Oil

Journal of the American Oil Chemists' Society, EarlyView.
This work advances sustainable chemistry by converting renewable castor oil into high‐performance estolides via solvent‐free, low‐energy catalysis. ABSTRACT Estolides are oligomers composed of fatty acid (FA) monomers linked through secondary ester bonds located along the mid‐chain region.
Lucas Natã de Melo, Simoni Margareti Plentz Meneghetti, Mario Roberto Meneghetti, Janaína Heberle Bortoluzzi   +3 more
wiley   +1 more source

Environmental and Genetic Effects on the Composition of Palm Oil From Hybrid Plant Clones of Caiaué and Oil Palm

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT The interspecific hybrids (IEH OxG) obtained from the crossing of Elaeis oleifera (Eo) and Elaeis guineensis (Eg) are resistant to some diseases that affect Eg in some regions of South America, and commercial growing in several countries has been established.
Rosemar Antoniassi, Ricardo Lopes, Sidney Pacheco, Allan Eduardo Wilhelm, Rui Alberto Gomes Junior, Adelia Ferreira de Faria‐Machado, Raimundo Nonato Vieira Cunha   +6 more
wiley   +1 more source

Green and climate colonialities: Evidence from Arctic extractivisms

Journal of Political Ecology
This article examines 16 environmental conflicts across the Arctic that demonstrate resistance to both climate and green extractive colonialisms. Resistance movements counter green-labelled developments, such as a 350 km road project in Ambler (Alaska ...
Joan Martinez-Alier, Ksenija Hanacek, Markus Kroger   +2 more
doaj   +2 more sources

Microwave‐Assisted Alcoholysis of Ethylene–Vinyl Acetate: Phenomenological and Thermal Evolution of EVAOH Terpolymers

Journal of Applied Polymer Science, EarlyView.
Microwave‐assisted alcoholysis converts EVA into EVAOH terpolymers, promoting a progressive transition from EVA‐like crystallites to VOH‐rich hydrogen‐bonded crystalline domains. Solvent‐controlled swelling influences conversion kinetics, while thermal analysis reveals a sigmoidal increase in melting temperature that a two‐population crystallization ...
Fernanda Trindade Gonzalez Dias, Aline Benittes dos Santos, Lucas Dall Agnol, Otávio Bianchi   +3 more
wiley   +1 more source