Results 11 to 20 of about 91,593 (205)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Revista Colombiana de Ciencia Animal Recia, 2023 The objective of this experiment was to evaluate three harvest strategies of corn intercropped with pigeon pea + Palisade grass on weight gain since grazing through finishing.
Beatriz Ligoski Cabral +7 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Challenges to access health faced by rural population and their perception regarding healthcare
Acta Scientiarum. Health Sciences, 2021 The Brazilian nation has rich population diversity, and this makes it responsible for guaranteeing the social rights of all. In this perspective, this research seeks to categorize which are the main challenges in access to health that the rural ...
Maria Maiely Bezerra Gomes +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Brucelose bovina: situação epidemiológica em rebanhos no município de Codó-MA
Pubvet, 2018 A brucelose é uma doença infecciosa, provocada por bactérias do gênero Brucella abortus. Essa doença pode causar perda da libido e infertilidade nos machos, abortos e endometrites em fêmeas.
Oswaldo Palma Lopes Sobrinho +10 more
doaj +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Semina: Ciências Agrárias, 2019 The objective of this study was to evaluate different pre-germination treatments, histochemical characteristics and physiological performance of Sapindus saponaria L. seeds as a function of temperature and the germination substrate. The S.
Ana Lúcia Cabral +6 more
doaj +1 more source
Uma revisão bibliográfica de medidas de eficiência energética em edifícios
Boletim do Observatório Ambiental Alberto Ribeiro Lamego, 2021 Mediante o aumento da demanda energética aliado ao crescimento populacional e econômico, o estudo sobre eficiência energética constitui uma importante ferramenta para a estruturação de um futuro sustentável, tanto para as questões econômicas quanto para ...
Mariáh Pereira Soares Pessanha Soares +5 more
doaj +1 more source