Results 11 to 20 of about 30,246 (153)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Edição Completa

C&T, 2020
Como demonstra o conjunto de temas elencados em artigo especial nesta edição, a COVID-19 foi o alvo de importantes trabalhos conduzidos por pesquisadores do Instituto Militar de Engenharia (IME). Foram construídos painéis de monitoramento e simulações da
Revista Militar de Ciência e Tecnologia
doaj   +2 more sources

Challenges to access health faced by rural population and their perception regarding healthcare

Acta Scientiarum. Health Sciences, 2021
The Brazilian nation has rich population diversity, and this makes it responsible for guaranteeing the social rights of all. In this perspective, this research seeks to categorize which are the main challenges in access to health that the rural ...
Maria Maiely Bezerra Gomes, Silvana Cavalcanti dos Santos, Jefferson Nunes dos Santos, Valdirene Pereira da Silva Carvalho, Ana Karine Laranjeira de Sá, Cláudia Fabiane Gomes Gonçalves, Valquíria Farias Bezerra Barbosa, Nelson Miguel Galindo Neto   +7 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Brucelose bovina: situação epidemiológica em rebanhos no município de Codó-MA

Pubvet, 2018
A brucelose é uma doença infecciosa, provocada por bactérias do gênero Brucella abortus. Essa doença pode causar perda da libido e infertilidade nos machos, abortos e endometrites em fêmeas.
Oswaldo Palma Lopes Sobrinho, Glayde Maria Carvalho Véras, Lana Fernanda Borges da Silva, Luciana dos Santos Oliveira, Rosinete dos Santos Xavier, Jorgeana Francis Alvim, Denise Arrais da Silva Costa, Álvaro Itaúna Schalcher Pereira, Maria da Assunção Silva Carlosa, Erika de Kássia Pereira Cantanhede, Maria de Lurdes Campos dos Santos   +10 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Dormancy breakage and germination in Sapindus saponaria L. seeds as a function of temperature and germination substrate

Semina: Ciências Agrárias, 2019
The objective of this study was to evaluate different pre-germination treatments, histochemical characteristics and physiological performance of Sapindus saponaria L. seeds as a function of temperature and the germination substrate. The S.
Ana Lúcia Cabral, Juliana de Fátima Sales, Karine Feliciano Barbosa, Arthur Almeida Rodrigues, Jacson Zuchi, Jennifer Maiara Domingues Silva, Sebastião Carvalho Vasconcelos Filho   +6 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source