Results 71 to 80 of about 30,246 (153)

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Linhas de esperança: oficina de crochê como ferramenta de capacitação e inclusão para mulheres em vulnerabilidade social no interior do Maranhão

Cadernos Cajuína
O presente projeto teve como objetivo promover a capacitação e a inclusão social e econômica de mulheres em situação de vulnerabilidade no interior do Maranhão, por meio de oficinas de crochê voltadas ao desenvolvimento de habilidades manuais e ...
Reysi Jhayne Pegorini, Frederico Augusto Abrantes Souza, Ruylon Calheiro Peixoto, Eduardo de Souza Moreira, Weverton Filgueira Pacheco, Florisval Protasio da Silva Filho, Gabriela Luz Pereira Moreira   +6 more
doaj   +1 more source

EDUCAÇÃO AMBIENTAL NO ENSINO MÉDIO A PARTIR DA AVALIAÇÃO DA QUALIDADE DA ÁGUA SUBTERRÂNEA CONSUMIDA EM LOCALIDADES DE SÃO JOÃO DA BARRA/RJ

Revista Águas Subterrâneas, 2012
Devido à exigência de mão de obra qualificada para o complexo logístico e portuário do Açu, do grupo EBX, a população de São João da Barra/RJ vem aumentando assim como o uso da água e os resíduos gerados, os quais podem comprometer o lençol freático.
TAYNÁ DE SOUZA GOMES SIMÕES, TÂMMELA CRISTINA GOMES NUNES, BRUNA SIQUEIRA CORRÊA, WILLIANS SALLES CORDEIRO, VICENTE DE PAULO SANTOS DE OLIVEIRA   +4 more
doaj  

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Physicochemical Analysis of Honey Produced and Sold in the Municipality of Senhor do Bonfim, Bahia

Acta Scientiarum: Animal Sciences
The objective of this study was to analyze the physicochemical characteristics of Apis mellifera L. honey produced and sold in Senhor do Bonfim, Bahia, Brazil.
Willhams Andrade Silva , Claudete Maria da Silva Moura , Alessandra Oliveira de Araújo , Laianne Oliveira Santos , Rafael Abílio de Sousa Silva , Paulo Leonardo Lima Ribeiro , Glayciane Costa Gois   +6 more
doaj   +1 more source

Pracaxi Oil as a Potential Inhibitor of Fat Bloom

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Fat bloom is one of the major technological challenges faced by the chocolate industry, caused by the polymorphic transition from β2(V) to β1(VI) crystals in cocoa butter (CB). One strategy to slow down this polymorphic transition is the addition of lipids rich in very long chain fatty acids (VLCFA), such as behenic acid.
Victoria Marques Gropelli, Priscila Dayane De Freitas Santos, Thayná Torres Da Silva, Ana Paula Badan Ribeiro, Rosiane Lopes Cunha   +4 more
wiley   +1 more source

Alkali‐Catalyzed Synthesis of Acylglycerol Estolides Exclusively from Castor Oil

Journal of the American Oil Chemists' Society, EarlyView.
This work advances sustainable chemistry by converting renewable castor oil into high‐performance estolides via solvent‐free, low‐energy catalysis. ABSTRACT Estolides are oligomers composed of fatty acid (FA) monomers linked through secondary ester bonds located along the mid‐chain region.
Lucas Natã de Melo, Simoni Margareti Plentz Meneghetti, Mario Roberto Meneghetti, Janaína Heberle Bortoluzzi   +3 more
wiley   +1 more source

Environmental and Genetic Effects on the Composition of Palm Oil From Hybrid Plant Clones of Caiaué and Oil Palm

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT The interspecific hybrids (IEH OxG) obtained from the crossing of Elaeis oleifera (Eo) and Elaeis guineensis (Eg) are resistant to some diseases that affect Eg in some regions of South America, and commercial growing in several countries has been established.
Rosemar Antoniassi, Ricardo Lopes, Sidney Pacheco, Allan Eduardo Wilhelm, Rui Alberto Gomes Junior, Adelia Ferreira de Faria‐Machado, Raimundo Nonato Vieira Cunha   +6 more
wiley   +1 more source

Valorization of Post‐Consumer Waste From Metallized Flexible Packaging and Industrial EPM Waste: Development of Sustainable Composites

Journal of Applied Polymer Science, EarlyView.
Post‐consumer metallized flexible packaging waste and industrial EPM waste are transformed into sustainable composites through mechanical recycling. The incorporation of 30 wt% EPM provides the most favorable balance between stiffness, ductility, and impact resistance, achieving 53.36 kJ/m2.
Tiago O. Oliveira, Samara L. Santos, Ruth M. C. Santana   +2 more
wiley   +1 more source

Compositional Time–Temperature–Transformation and Post‐Processing Window Mapping of Epoxy Nanocomposites via Machine Learning

Journal of Applied Polymer Science, EarlyView.
Discrete DSC and rheological data are transformed into continuous compositional Time–temperature–transformation (TTT) diagrams through physics‐informed Gaussian Process Regression. The proposed framework quantitatively predicts post‐gel processing windows across temperature and nanofiller composition, providing a practical route for accelerated design ...
Otávio Bianchi, Dante A. Benvenutti, Leonardo B. Canto, Alessandra Lavoratti, Zainab Al‐Maqdasi, Sandro Campos Amico, Patrik Fernberg   +6 more
wiley   +1 more source