Results 141 to 150 of about 67,262 (259)

Altered volumetric and functional connectivity of the habenula in chronic insomnia disorder. [PDF]

Front Neurosci
Sun J, Zhang K, Li P, Xu W, Ding K, Zhang B, Zhao B, Zhang D.   +7 more
europepmc   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Identifying patients with mild-to-moderate COPD who require intensified initial treatment to control annualized clinically important deterioration. [PDF]

NPJ Prim Care Respir Med
Wang Z, Zhou Y, Guan WJ, Lin J, Cai G, Zheng J, Wu F, Deng Z, Zhong NS, Ran P.   +9 more
europepmc   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Comprehensive characterization of the inflammatory ecosystems in immunotherapy-induced adverse events versus chronic inflammatory diseases. [PDF]

J Immunother Cancer
Kang J, An J, Choi JK.
europepmc   +1 more source

Combining Laser‐Induced Edition to Collision‐Induced Sequencing of Digital Oligomers in a Single Gas‐Phase Experiment

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino, Jean‐François Lutz, Luke MacAleese, Laurence Charles   +3 more
wiley   +1 more source

Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia. [PDF]

J Alzheimers Dis
Levine DA, Hayward RA, Sussman JB, Whitney RT, Gałecki AT, Briceño EM, Gross AL, Giordani BJ, Elkind MSV, Gaskin DJ, Gottesman RF, Sidney S, Yaffe K, Burke JF.   +13 more
europepmc   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure. [PDF]

J Cell Biol
Park JH, Liu RJY, Sun X, Mahalingan KK, Hiriyanna S, Li T, Roll-Mecak A.   +6 more
europepmc   +1 more source

Electron Transfer Dissociation and Synchrotron UV Photodissociation of Trapped Sodiated Ions Produced From Polyacrylates by Electrospray Ionization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Poly (acrylates)s can be distinguished from one another by the nature of their side chains. From model poly (acrylates)s, the purpose of this work was to evaluate the contribution of alternative activation techniques to the collisional activation, based on ion–ion and ion–photon interactions.
Inès Aloui, Véronique Legros, Cédric Przybylski, Matthieu Bourderioux, Alexandre Giuliani, William Buchmann   +5 more
wiley   +1 more source