Results 51 to 60 of about 528,483 (278)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection

Angewandte Chemie, EarlyView.
In this research, we show the concept of molecular cages as probes in indicator displacement assays, focusing on scopolamine detection, a drug often used in drug‐facilitated sexual assaults. Drug sensing occurs via the drug‐induced transformation of non‐emissive [Fluorescein2⊂Cage] complex into [Scopolamine⊂Catenane] and highly emissive free ...
Giovanni Montà‐González, Eva Garrido, Estela Climent, Cristian Vicent, Ramón Martínez‐Máñez, Vicente Martí‐Centelles   +5 more
wiley   +2 more sources

Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells

Scientific Reports
The development of effective and long-lasting malaria vaccines remains a key goal. Late-arresting genetically attenuated sporozoite (LA-GAP SPZ) vaccines, such as Pf∆mei2 (GA2), have shown strong protective potential.
Roos van Schuijlenburg, Chanel M. Naar, Helena M. de Bes-Roeleveld, Séverine Chevalley-Maurel, Lili A. Zigó, Emma L. Houlder, Joost M. Lambooij, Els Baalbergen, Meta Roestenberg, Blandine Franke-Fayard   +9 more
doaj   +1 more source

De las mocedades de Castro al Cid de Corneille [PDF]

, 2019
Este trabajo recorre los parámetros que permiten comparar Le Cid de Pierre Corneille (1637) con su fuente, Las mocedades del Cid, comedia primera de Guillén de Castro (1618).
Serrano Deza, Ricardo
core   +1 more source

Scalable, Microwave‐Enabled Synthesis of Ternary WxTi1‐xO2 and Heterostructured TiO2‐WO3‐x Colloidal Nanocrystals: Carrier Dynamics and Photocatalytic Properties

Advanced Science, EarlyView.
Two microwave‐assisted synthetic methods, specifically a one‐pot and a seeded‐growth approach, are developed within a hydroalcoholic solution for the growth of single‐phase ternary WxTi1‐xO2 and heterostructured TiO2‐WO3‐x colloidal nanocrystals. Both types of nanocrystals show significant photocatalytic activity for 4‐methoxybenzyl alcohol oxidation ...
Riccardo Scarfiello, Michele Guizzardi, Angela Fiore, Armando Genco, Concetta Nobile, Elisabetta Perrone, Sara Fernanda Orsini, Clémentine Fellah, Lucian Roiban, Marianna Bellardita, Anna Maria Venezia, Giulio Cerullo, Leonardo Palmisano, Luigi Carbone   +13 more
wiley   +1 more source

Classificação Internacional de Doenças e Problemas Relacionados à Saúde (CID-11)

Asklepion, 2021
Desde seus primórdios, a Classificação Internacional de Doenças e Problemas Relacionados à Saúde (CID) foi revisada e publicada com alguma periodicidade para refletir os avanços da saúde, da ciência e da sociedade.
Maria Cristiane Barbosa Galvão, Ivan Luiz Marques Ricarte   +1 more
doaj   +1 more source

Multi‐Soliton Microcombs Enable Ultrafast Nanometric‐Precision Ranging and Photon‐Level Detection

Advanced Science, EarlyView.
Our work first demonstrates dual‐multi‐soliton ranging and confirms its multifunctional capability. The method achieves ultrafast and nanometric‐precision measurement. For practical applications, we further extend the multi‐soliton states to photon‐level ranging.
Jiawen Zhi, Xiaoyang Guo, Xusheng Yang, Brent E. Little, Sai T. Chu, Chenggang Shao, Mengyu Wang, Yan Liang, Peng Xie, Weiqiang Wang, Hanzhong Wu   +10 more
wiley   +1 more source

Enhanced Peptide Identification by Electron Transfer Dissociation Using an Improved Mascot Percolator [PDF]

, 2012
Peptide identification using tandem mass spectrometry is a core technology in proteomics. Latest generations of mass spectrometry instruments enable the use of electron transfer dissociation (ETD) to complement collision induced dissociation (CID) for ...
Appella, Baker, Biemann, Brosch, Chalkley, Chi, Craig, Desiere, Deutsch, Domon, Geer, Good, Good, Granholm, Gupta, Hart, Kandasamy, Klimek, Käll, Käll, Liu, McAlister, Mikesh, Molina, Molina, Nagaraj, Perkins, Sadygov, Spivak, Swaney, Swaney, Sweet, Syka, Vizcaino, Wenger, Wiesner, Zubarev   +36 more
core   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

The International Classification of Diseases, the Family of International Classifications, The ICD-11, and Post-Polio Syndrome [PDF]

, 2013
The first International Classification of Diseases (ICD) was approved in 1893 and since then it has been periodically reviewed. The last, 10th revision (ICD-10), was approved in 1989.
Conde, Monica Tilli Reis Pessoa, Laurenti, Ruy, Nubila, Heloisa Brunow Ventura Di, Oliveira, Acary Souza Bulle, Quadros, Abrahao Augusto Joviniano   +4 more
core   +3 more sources