Results 141 to 150 of about 52,278 (220)

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Correction: Fetal Pulmonary Venous Return: From Basic Research to the Clinical Value of Doppler Assessment. [PDF]

Pediatr Cardiol
Dias JP, Guedes-Martins L.
europepmc   +1 more source

Discovery of [1,2,4]triazolo[1,5‐a]pyrimidine‐Imatinib Hybrids With Selective Cytotoxic Activity: A Mechanistically Divergent Series From Direct BCR‐ABL1 Inhibition

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Discovery of imatinib–triazolopyrimidine hybrids with selective cytotoxicity and a mechanism distinct from classical BCR‐ABL1 inhibition. This bioisosteric strategy introduces a novel compounds, paving the way for innovative antileukemic therapies with differentiated profiles.
Stefany Castro Bazan Moura, Andressa Paula de Oliveira, Joao de Mello Rezende Neto, Rafael Ferreira Dantas, Floriano Paes Silva‐Jr, Luiz Claudio Pimentel, Mayara Salles do Nascimento Carvalho, Debora Inacio Leite, Daiane Vitoria da Silva, Monica Macedo Bastos, Nubia Boechat   +10 more
wiley   +1 more source

Análisis de las comunidades científicas y académicas de las ciencias básicas médicas y de la salud pública en Colombia ¿una diferencia? [PDF]

El objetivo de este trabajo es caracterizar la dinámica de los recursos humanos en investigación y su producción científica al interior de las comunidades de salud pública y ciencias básicas biomédicas del país.
Carolina Lopera Oquendo, Hernán Jaramillo Salazar   +1 more
core  

Gestational High-Fat Diet Drives Premature Differentiation of Orexigenic Neurons and Reactivity of Astrocytes in the Fetal Rat Lateral Hypothalamus. [PDF]

Brain Sci
Galindo-Solano N, Trejo-Villarreal X, Díaz-Olivares G, Rea-Palomino G, Montes-Aguirre D, Villagrán-Santa-Cruz M, Gutiérrez-Ospina G.   +6 more
europepmc   +1 more source

Seroepidemiological survey to investigate Rickettsia rickettsii and Rickettsia parkeri in municipalities of the southeast Brazil. [PDF]

Rev Inst Med Trop Sao Paulo
Franco MB, Fonseca GC, Sousa ACP, Rostkwoska C, Pajuaba ACAM, Mineo JR, Szabó MPJ, Oliveira SV.   +7 more
europepmc   +1 more source

Loss of Macrophage Migration Inhibitory Factor (MIF) Alters the Timing of Ventral Prostate Maturation in Mice. [PDF]

J Histochem Cytochem
Matos JEM, Silva MDGCE, Sudário LED, Peixoto LFF, Zanon RG, Ribeiro DL.   +5 more
europepmc   +1 more source

Correction: Serrasqueiro et al. Targeting the Mannose Receptor with Functionalized Fucoidan/Chitosan Nanoparticles Triggers the Classical Activation of Macrophages. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 9908. [PDF]

Int J Mol Sci
Serrasqueiro F, Barbosa AI, Lima SAC, Reis S.   +3 more
europepmc   +1 more source

Caracterización de los trabajos presentados en la Primera Edición del Evento Ciencia e Innovación Médica

Universidad Médica Pinareña
Introducción: el Capítulo de Ciencias Básicas Biomédicas del Consejo Provincial de Sociedades Científicas, en conjunto con la Federación Estudiantil Universitaria (FEU) de la Universidad de Ciencias Médicas de Guantánamo, desarrollaron el 13 de octubre ...
Dariel Marín-González, Cynthia Reyes-Flores, María Esther Prampen-Rojas   +2 more
doaj  

Cardiovascular risk scores, non-invasive vascular measures and myositis damage index reveal increased cardiovascular risk in idiopathic inflammatory myopathies: a case-control study. [PDF]

BMC Rheumatol
Garcia-Ordoñez GP, Ramos-Becerra CG, Corona-Meraz FI, Salazar-Paramo M, Perez-Vazquez F, Quirarte-Tovar EF, Juarez-Gomez C, Aguilar-Vazquez A, Vazquez-Del Mercado M.   +8 more
europepmc   +1 more source