Results 81 to 90 of about 52,278 (220)

Revisão de parâmetros ARRIVE em artigos de revistas científicas chilenas indexadas pela Thomson Reuters, que utilizam animais de experimentação in vivo, entre 2010 e 2012 [PDF]

, 2015
We propose to know the national situation regarding scientific publishing using experimental animals, based on the guidelines ARRIVE (Animal Research: Reporting In Vivo Experiments) for animal research.
Galindo, Leslie, Jiménez, Eliana, Luzio, Álvaro, Troncoso, Ignacio, Ureña, Diana   +4 more
core   +2 more sources

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

Fundación de la Sociedad Cubana de Ciencias Morfológicas

Revista Habanera de Ciencias Médicas, 2013
RESUMENEl Instituto de Ciencias Básicas y Preclínicas "Victoria de Girón" se fundó en La Habana en octubre de 1962. Allí se inició el desarrollo de las Ciencias Básicas Biomédicas en Cuba, hasta convertirse en el centro rector para su enseñanza ...
Irene De la C. Rodríguez Pérez, Rosa María Coro Antich, Belén Zenaida Iglesias Ramírez   +2 more
doaj  

Perspectivas de la experimentación animal en ciencias biomédicas [PDF]

, 2016
En la presente revisión bibliográfica se pretende realizar un ejercicio de divulgación científica de un tema tan controvertido como es la experimentación con animales en los últi¬mos siglos, los orígenes, sujetos y objetivos de esta práctica, el estado ...
Largo Bermejo, Juan Daniel, Míguez Santiyán, María Prado, Pérez López, Marcos   +2 more
core   +1 more source

Identification and detection of iha subtypes in LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated from humans, cattle and food [PDF]

, 2019
LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains are important cause of infection in humans and they should be included in the public health surveillance systems.
Colello, Rocío, Del Canto, Felipe, Etcheverría, Analía Inés, Krüger, Alejandra, Padola, Nora Lía, Velez, María Victoria, Vidal, Roberto   +6 more
core   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Fontes para a história das ciências da saúde no Brasil (1808-1930) Sources for the history of health sciences in Brazil (1808-1930)

História, Ciências, Saúde: Manguinhos, 2002
O objetivo deste estudo é apresentar um panorama das fontes documentais e dos arquivos, bibliotecas e centros de documentação representativos para a história das ciências da saúde no Brasil (1808-1930).
Maria Rachel Fróes da Fonseca
doaj   +1 more source

Analysis of biological diversity and miscegenation in the city of Puerto Madryn (Prov.of Chubut, Argentina) [PDF]

, 2013
En el marco del estudio de la composición genética de las poblaciones cosmopolitas de Argentina, se analizó una muestra poblacional de la localidad de Puerto Madryn (PM) con la finalidad de evaluar su diversidad biológica mediante la utilización de ...
Avena, Sergio Alejandro, Carnese, Francisco Raul, Dahinten, Silvia Lucrecia V., Dejean, Cristina B., Di Fabio Rocca, Francisco, Fleischer, Silvina, Manera, Guillermo, Parolin, María Laura, Postillone, María Bárbara, Pretell, Mariana, Rodriguez, Debora A., Vaccaro, Maria S.   +11 more
core   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source