Subtype-Selective Positive Modulation of K\u3csub\u3eCa\u3c/sub\u3e2.3 Channels Increases Cilia Length [PDF]
, 2022 Small-conductance Ca2+-activated potassium (KCa2.x) channels are gated exclusively by intracellular Ca2+. The activation of KCa2.3 channels induces hyperpolarization, which augments Ca2+ signaling in endothelial cells.
Amirrad, Farideh +11 more
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Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
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Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J +14 more
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
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PLoS Computational Biology, 2017 Mucociliary clearance is one of the major lines of defense of the respiratory system. The mucus layer coating the pulmonary airways is moved along and out of the lung by the activity of motile cilia, thus expelling the particles trapped in it.
Mathieu Bottier +10 more
doaj +1 more source
Physiological flow of biomedical compressible fluids inside a ciliated symmetric channel
Advances in Mechanical Engineering, 2020 This article studies the flow induced by cilia for a compressible Jeffrey fluid. The investigation is carried out for electrically conducting magnetohydrodynamic fluid in a space of porous media. The fluid flows inside a two-dimensional symmetric channel.
Anber Saleem +2 more
doaj +1 more source
dmrt2 and myf5 Link Early Somitogenesis to Left-Right Axis Determination in Xenopus laevis
Frontiers in Cell and Developmental Biology, 2022 The vertebrate left-right axis is specified during neurulation by events occurring in a transient ciliated epithelium termed left-right organizer (LRO), which is made up of two distinct cell types.
Melanie Tingler +3 more
doaj +1 more source
Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)
Bioengineering, 2023 The kidney proximal tubule (PT) mediates renal drug elimination in vivo and is a major site of drug-induced toxicity. To reliably assess drug efficacy, it is crucial to construct a model in which PT functions are replicated.
Francesca Pisapia +4 more
doaj +1 more source
An all-optical approach for probing microscopic flows in living embryos [PDF]
, 2008 Living systems rely on fluid dynamics from embryonic development to adulthood. To visualize biological fluid flow, devising the proper labeling method compatible with both normal biology and in vivo imaging remains a major experimental challenge.
Bartman +17 more
core +3 more sources
Case Studies in Thermal Engineering, 2023 The present study is a measurement of the thermal and mass transfer of a two-layered flow of viscous fluid induced by cilia motion under the effect of buoyancy forces through a channel.
Nahid Fatima +5 more
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