Results 31 to 40 of about 256,965 (211)
Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease [PDF]
, 2007 SummaryThe assembly of primary cilia is dependant on intraflagellar transport (IFT), which mediates the bidirectional movement of proteins between the base and tip of the cilium.
Croyle, Mandy J. +8 more
core +1 more source
Hydrodynamic flow patterns and synchronization of beating cilia [PDF]
Phys. Rev. Lett. 96, 058102 (2006), 2005 We calculate the hydrodynamic flow field generated far from a cilium which is attached to a surface and beats periodically. In the case of two beating cilia, hydrodynamic interactions can lead to synchronization of the cilia, which are nonlinear oscillators.
arxiv +1 more source
Probing cilia-driven flow in living embryos using femtosecond laser ablation and fast imaging [PDF]
, 2009 Embryonic development strictly depends on fluid dynamics. As a consequence, understanding biological fluid dynamic is essential since it is unclear how flow affects development.
Fraser, Scott E. +2 more
core +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Nonlinear Dynamics of Cilia and Flagella [PDF]
Phys. Rev. E 79, 051918 (2009), 2009 Cilia and flagella are hair-like extensions of eukaryotic cells which generate oscillatory beat patterns that can propel micro-organisms and create fluid flows near cellular surfaces. The evolutionary highly conserved core of cilia and flagella consists of a cylindrical arrangement of nine microtubule doublets, called the axoneme.
arxiv +1 more source
Spontaneous phase coordination and fluid pumping in model ciliary carpets [PDF]
, 2022 Ciliated tissues such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by the collective activity of hundreds of thousands of individual cilia that beat in a striking metachronal wave pattern.
arxiv +1 more source
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]
, 2012 Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann +51 more
core +2 more sources
PLoS Computational Biology, 2017 Mucociliary clearance is one of the major lines of defense of the respiratory system. The mucus layer coating the pulmonary airways is moved along and out of the lung by the activity of motile cilia, thus expelling the particles trapped in it.
Mathieu Bottier +10 more
doaj +1 more source
Physiological flow of biomedical compressible fluids inside a ciliated symmetric channel
Advances in Mechanical Engineering, 2020 This article studies the flow induced by cilia for a compressible Jeffrey fluid. The investigation is carried out for electrically conducting magnetohydrodynamic fluid in a space of porous media. The fluid flows inside a two-dimensional symmetric channel.
Anber Saleem +2 more
doaj +1 more source
dmrt2 and myf5 Link Early Somitogenesis to Left-Right Axis Determination in Xenopus laevis
Frontiers in Cell and Developmental Biology, 2022 The vertebrate left-right axis is specified during neurulation by events occurring in a transient ciliated epithelium termed left-right organizer (LRO), which is made up of two distinct cell types.
Melanie Tingler +3 more
doaj +1 more source