Results 101 to 110 of about 4,592,681 (317)

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Convergent differentiation of multiciliated cells

Scientific Reports, 2023
Multiciliated cells (MCCs) are epithelial cells that control body fluid flow and contribute to the clearance of pathogenic microbes and other particles from the airways, egg transport in oviducts, and circulation of cerebrospinal fluid in the central ...
Shinhyeok Chae, Tae Joo Park, Taejoon Kwon   +2 more
doaj   +1 more source

Advances in 3D and 4D Printing of Soft Robotics and Their Applications

Advanced Intelligent Systems, EarlyView.
This article summarizes the development of 3D‐printed soft robotics in the recent decade. The article discusses the printing capabilities of different additive manufacturing technologies in terms of soft polymers, multimaterial printability, soft robotic printing, and 4D printing.
Hao Liu, Changchun Wu, Senyuan Lin, James Lam, Ning Xi, Yonghua Chen   +5 more
wiley   +1 more source

Symmetry Breaking Metamaterial Sleeve Actuators

Advanced Intelligent Systems, EarlyView.
Metamaterial sleeves are designed to impart to a soft inflatable structure, nonlinear characteristics within the pressure–volume domain. By tuning the unit cells of the metamaterial sleeve, symmetry breaking is achieved during the inflation–deflation cycle.
Imran Qayyum Mundial, Alexis Van Merris, Edoardo Milana, Benjamin Gorissen   +3 more
wiley   +1 more source

The Geometry of Ciliary Dynamics [PDF]

, 2009
Cilia are motile biological appendages that are driven to bend by internal shear stresses between tubulin filaments. A continuum model of ciliary material is constructed that incorporates the essential ciliary constraints: (1) one-dimensional inextensibility of filaments, (2) three-dimensional incompressibility, and (3) shear strain only along ...
arxiv   +1 more source

Ciliary propulsion through non-uniform flows

Journal of Fluid Mechanics
The classical paper by Lighthill (Commun. Pure Appl. Maths, vol. 109, 1952, p. 118) on the propulsion of ciliated microorganisms has become the reference against which many modern studies on swimming in low Reynolds number are compared. However, Lighthill's study was limited to propulsion in a uniform flow, whereas several biologically relevant ...
H. Nganguia, D. Palaniappan
openaire   +2 more sources

Viscous dissipation effects on the thermal radiatively induced micropolar fluid using the metachronal wave of cilia in the presence of slip constraints

Advances in Mechanical Engineering
Cilia motion is commonly located in mammalian cells of living organisms which continually grow and feature conspicuously. The ciliary apparatus is associated with cell cycle movement and proliferation, and cilia play a dynamic part in human and animal ...
Muhammad Yousuf Rafiq, Zaheer Abbas, Arshia Tariq, Anum Durrani, Sabeeh Khaliq   +4 more
doaj   +1 more source

Elastohydrodynamic phase-lock in two rotating cilia

Journal of Biomechanical Science and Engineering, 2017
Determination of left-right asymmetry of the body plan is achieved in the early embryo. At the 4-6 somite stage, a cavity structure, called a node, is observed in the ventral midline surface, in which hundreds of cilia rotate.
Toshihiro OMORI, Mingming LU, Takuji ISHIKAWA   +2 more
doaj   +1 more source