Results 181 to 190 of about 4,592,681 (317)

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca²⁺ signaling [PDF]

, 2006
Chang Xu, Sandro Rossetti, Lianwei Jiang, Peter C. Harris, Ursa Brown-Glaberman, Angela Wandinger‐Ness, Robert L. Bacallao, Seth L. Alper   +7 more
openalex   +1 more source

Acute Neuropsychiatric Decline in a Parkinson's Disease Patient with a Severe GBA1 Mutation Following Bilateral GPi Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Vijay G. Palakuzhy, Gian D. Pal, Mitra Afshari   +2 more
wiley   +1 more source

Immunotherapeutic targeting of aging‐associated isoDGR motif in chronic lung inflammation

Aging Cell, Volume 24, Issue 4, April 2025.
Accumulation of isoDGR‐damaged proteins in aged lung tissues leads to macrophage infiltration and chronic inflammation. Anti‐isoDGR antibodies treatment clears isoDGR proteins and reduces inflammation and lung damage. Abstract Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age‐related chronic diseases. Since this
Pazhanichamy Kalailingam, SoFong Cam Ngan, Ranjith Iyappan, Afra Nehchiri, Khalilatul‐Hanisah Mohd‐Kahliab, Benjamin Sian Teck Lee, Bhargy Sharma, Radek Machan, Sint Thida Bo, Emma S. Chambers, Val A. Fajardo, Rebecca E. K. Macpherson, Jian Liu, Panagiota Klentrou, Evangelia Litsa Tsiani, Kah Leong Lim, I. Hsin Su, Yong‐Gui Gao, A. Mark Richar, Raj N. Kalaria, Christopher P. Chen, Cynthia Balion, Dominique de Kleijn, Neil E. McCarthy, Siu Kwan Sze   +24 more
wiley   +1 more source

A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow. [PDF]

Invest Ophthalmol Vis Sci
Tweedy JH, Dvoriashyna M, Crawshaw JR, Overby DR, Repetto R, Roberts PA, Spelman TA, Stewart PS, Foss AJE.   +8 more
europepmc   +1 more source

Role of PI3K/AKT/MAOA in glucocorticoid‐induced oxidative stress and associated premature senescence of the trabecular meshwork

Aging Cell, Volume 24, Issue 4, April 2025.
Glucocorticoids activated the PI3K/AKT/MAOA pathway, leading to mitochondrial dysfunction, oxidative stress, and premature aging in TM, elevating IOP. Abstract The oxidative stress‐induced premature senescence of trabecular meshwork (TM) represents a pivotal risk factor for the development of glucocorticoid‐induced glaucoma (GIG).
Pengyu Zhang, Nan Zhang, Yixin Hu, Xizhi Deng, Min Zhu, Cheng Lai, Wen Zeng, Min Ke   +7 more
wiley   +1 more source

Interpretation of expert consensus on the application of low‐concentration atropine eye drops in the prevention and control of myopia in children and adolescents

Pediatric Investigation, EarlyView.
Li Li
wiley   +1 more source

Ciliary Ion Channels in Polycystic Kidney Disease. [PDF]

Cells
Alshriem LA, Buqaileh R, Alorjani Q, AbouAlaiwi W.   +3 more
europepmc   +1 more source

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, Volume 24, Issue 5, May 2025.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source

Effects of ocular hypothermia: potential perspectives in vitreoretinal surgery. [PDF]

Int J Retina Vitreous
Crincoli E, Carlà MM, Savastano A, Savastano M, Kilian R, Rizzo C, Caporossi T, Rizzo S.   +7 more
europepmc   +1 more source

KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease

Aging Cell, Volume 24, Issue 5, May 2025.
KIF9 is downregulated in AD, accompanied by dysfunction in macroautophagy. Genetic upregulation of KIF9 enhances macroautophagy by promoting KLC1‐mediated anterograde transport of lysosomes, which effectively reduces Aβ deposition and alleviates cognitive impairments in AD.
Maoju Wang, Song Guo, Lilin Yi, Zhaolun Li, Xiuyu Shi, YePeng Fan, Man Luo, Yan He, Weihong Song, Yehong Du, Zhifang Dong   +10 more
wiley   +1 more source