Results 241 to 250 of about 4,592,681 (317)

Investigating Aging‐Related Endometrial Dysfunction Using Endometrial Organoids

open access: yesCell Proliferation, Volume 58, Issue 4, April 2025.
Age‐associated fibrosis, imbalanced inflammatory homeostasis including Th1 bias in secretory phase, cellular senescence and decline of receptivity exist in human endometrium of advanced age. Overactivation of PI3K‐AKT‐FOXO1 signalling pathway could give rise to those characteristics above.
Minghui Lu   +9 more
wiley   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

open access: yesCell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai   +9 more
wiley   +1 more source

Airway Basal Stem Cells Inflammatory Alterations in COVID‐19 and Mitigation by Mesenchymal Stem Cells

open access: yesCell Proliferation, EarlyView.
Airway basal stem cells derived from COVID‐19 patients demonstrated pronounced goblet cell hyperplasia, inflammatory responses and tendencies toward fibrosis. Co‐culture with mesenchymal stem cells (MSCs) notably reduced these pathological changes, likely due to MSCs' regulatory effects on the interferon signalling pathway.
Sheng Du   +11 more
wiley   +1 more source

Ciliary IFT‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

open access: yesCell Proliferation, EarlyView.
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang   +17 more
wiley   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

open access: yesCell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma

open access: yes
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 264-266, March 2025.
Kirsten E. Stewart   +3 more
wiley   +1 more source

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