Effects of Flow Hydrodynamics and Eye Movements on Intraocular Drug Clearance
New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion and convection effects on intraocular clearance. Port placement in front ((i) ciliary inflow model) and behind the model lens ((ii) posterior inflow model)
Angeliki Velentza-Almpani +7 more
doaj +1 more source
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
doaj +1 more source
Purpose: To study the optic nerve vascular hemodynamics in patients with anterior ischemic optic neuropathy (AION) before and after application of the Alloplant biomaterial.Methods: The ultrasound diagnostic system General Electric Ultrasound Logic 7 (U.
V. U. Galimova, +3 more
doaj +3 more sources
Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva
Ciliated surfaces harbouring synchronously beating cilia can generate fluid flow or drive locomotion. In ciliary swimmers, ciliary beating, arrests, and changes in beat frequency are often coordinated across extended or discontinuous surfaces.
Csaba Verasztó +6 more
doaj +1 more source
Reynolds number limits for jet propulsion: A numerical study of simplified jellyfish [PDF]
The Scallop Theorem states that reciprocal methods of locomotion, such as jet propulsion or paddling, will not work in Stokes flow (Reynolds number = 0).
Herschlag, Gregory, Miller, Laura A.
core +3 more sources
A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla +2 more
core +1 more source
Ciliary motility activity measurement using a dense optical flow algorithm
Persistent respiratory syncytial virus (RSV) infections have been associated with the exacerbation of chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). This virus infects the respiratory epithelium, leading to chronic inflammation, and induces the release of mucins and the loss of cilia activity, two factors that ...
Parrilla Bernabé, Eduardo +6 more
openaire +4 more sources
Trapping study of nanofluids in an annulus with cilia
The main purpose of this article is to present a mathematical model of ciliary motion in an annulus. In this analysis, two dimensional flow of a viscous nanofluid is observed in an annulus with ciliated tips. The current theoretical model may be supposed
S. Nadeem, Hina Sadaf
doaj +1 more source
Matrix Metalloproteinases and Glaucoma Treatment. [PDF]
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed +3 more
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