Cimicifugoside H-2 as an Inhibitor of IKK1/Alpha: A Molecular Docking and Dynamic Simulation Study [PDF]
BiomoleculesOne of the most challenging issues scientists face is finding a suitable non-invasive treatment for cancer, as it is widespread around the world. The efficacy of phytochemicals that target oncogenic pathways appears to be quite promising and has gained ...
Shahd Aboul Hosn +4 more
doaj +2 more sources
Effect of the standardized Cimicifuga foetida extract on Hsp 27 expression in the MCF-7 cell line [PDF]
Biological Research, 2011 Cimicifuga foetida, an Asian Cimicifuga species, has been employed as a cooling and detoxification agent in traditional Chinese medicine since ancient times.
Maritza C Soler +7 more
doaj +4 more sources
Methanolic Extract of Cimicifuga foetida Induces G1 Cell Cycle Arrest and Apoptosis and Inhibits Metastasis of Glioma Cells. [PDF]
NutrientsBackground: Glioblastoma multiforme (GBM) is among the most aggressive and challenging brain tumors, with limited treatment options. Cimicifuga foetida, a traditional Chinese medicine, has shown promise due to its bioactive components. This study investigates the anti-glioma effects of a methanolic extract of C.
Chang CH, Tsai HP, Yen MH, Lin CJ.
europepmc +3 more sources
Chemical and Pharmaceutical Bulletin, 2010 Five new triterpene bisglycosides, foetidinosides A (1), B (2), C (3), D (4) and E (5), including three of the cycloartane type, one of its derivative, and one of the lanostane type were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated on the basis of spectroscopic data and chemical evidence.
Lu Lu, Jian-Chao Chen, Yin Nian
exaly +4 more sources
A Case of Severe Anemia in Pregnancy Treated With Traditional Chinese Medicine. [PDF]
Clin Case RepABSTRACT This case report describes the treatment of a 29‐year‐old pregnant woman with severe anemia using traditional Chinese medicine (TCM). The patient, at 5 weeks of gestation, presented with a hemoglobin level of 75 g/L and had a history of autoimmune hemolytic anemia and alpha‐thalassemia, which had previously led to pregnancy termination at 17 ...
Zhong S, Xie T.
europepmc +2 more sources
Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF-<i>κ</i>B Pathway. [PDF]
Stem Cells IntBackground Periodontitis refers to a chronic inflammatory illness that induces the destruction of periodontal tissues and can be driven by bacterial lipopolysaccharide (LPS) of pathogens. This study investigated the anti‐inflammatory potential and underlying mechanisms of ferulic acid (FA) in periodontitis.
Wang Q, Feng B, Gao Y.
europepmc +2 more sources
Therapeutic interventions aimed at cccDNA: unveiling mechanisms and evaluating the potency of natural products. [PDF]
Front Cell Infect MicrobiolHepatitis B virus (HBV) infection persists as a formidable global health predicament, imposing a substantial burden on public health. It not only elevates the risk of cirrhosis but also significantly heightens the incidence of hepatocellular carcinoma ...
Hao L, Li S, Hu X.
europepmc +3 more sources
Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition. [PDF]
Front Pharmacol, 2022 Hochuekkito (HET) is a Kampo medicine used to treat postoperative and post-illness general malaise and decreased motivation. HET is known to regulate immunity and modulate inflammation.
Ushio S +10 more
europepmc +4 more sources
Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies
CNS Neuroscience &Therapeutics, Volume 29, Issue 9, Page 2397-2412, September 2023., 2023 Abstract Depression is a common but severe mood disorder with a very high prevalence across the general population. Depression is of global concern and poses a threat to human physical and mental health. Ferulic acid (FA) is a natural active ingredient that has antioxidative, anti‐inflammatory, and free radical scavenging properties.
Xiaoyu Dong, Dongxue Zhao
wiley +1 more source
Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression-Associated Neuroinflammation. [PDF]
Adv Sci (Weinh)Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Guo D +7 more
europepmc +2 more sources