Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells [PDF]
Beilstein Journal of Organic Chemistry, 2007 Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A (1) and B (2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-β-D-xylopyranoside, 12β-hydroxycimigenol 3-O-β-D-xylopyranoside, cimigenol 3-O-α-L ...
Li-Rong Sun +8 more
doaj +2 more sources
Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF-<i>κ</i>B Pathway. [PDF]
Stem Cells IntBackground Periodontitis refers to a chronic inflammatory illness that induces the destruction of periodontal tissues and can be driven by bacterial lipopolysaccharide (LPS) of pathogens. This study investigated the anti‐inflammatory potential and underlying mechanisms of ferulic acid (FA) in periodontitis.
Wang Q, Feng B, Gao Y.
europepmc +2 more sources
Cimicifugoside H-2 as an Inhibitor of IKK1/Alpha: A Molecular Docking and Dynamic Simulation Study [PDF]
BiomoleculesOne of the most challenging issues scientists face is finding a suitable non-invasive treatment for cancer, as it is widespread around the world. The efficacy of phytochemicals that target oncogenic pathways appears to be quite promising and has gained ...
Shahd Aboul Hosn +4 more
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Effect of the standardized Cimicifuga foetida extract on Hsp 27 expression in the MCF-7 cell line [PDF]
Biological Research, 2011 Cimicifuga foetida, an Asian Cimicifuga species, has been employed as a cooling and detoxification agent in traditional Chinese medicine since ancient times.
Maritza C Soler +7 more
doaj +4 more sources
Methanolic Extract of Cimicifuga foetida Induces G1 Cell Cycle Arrest and Apoptosis and Inhibits Metastasis of Glioma Cells. [PDF]
NutrientsBackground: Glioblastoma multiforme (GBM) is among the most aggressive and challenging brain tumors, with limited treatment options. Cimicifuga foetida, a traditional Chinese medicine, has shown promise due to its bioactive components. This study investigates the anti-glioma effects of a methanolic extract of C.
Chang CH, Tsai HP, Yen MH, Lin CJ.
europepmc +3 more sources
Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression-Associated Neuroinflammation. [PDF]
Adv Sci (Weinh)Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Guo D +7 more
europepmc +2 more sources
Chemical and Pharmaceutical Bulletin, 2010 Five new triterpene bisglycosides, foetidinosides A (1), B (2), C (3), D (4) and E (5), including three of the cycloartane type, one of its derivative, and one of the lanostane type were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated on the basis of spectroscopic data and chemical evidence.
Minghua Qiu, Lu Lu, Yin Nian
exaly +4 more sources
Secondary Metabolites with Anti-Inflammatory from the Roots of Cimicifuga taiwanensis
Molecules, 2022 The genus Cimicifuga is one of the smallest genera in the family Ranunculaceae. Cimicifugae Rhizoma originated from rhizomes of Cimicifuga simplex, and C. dahurica, C. racemosa, C. foetida, and C.
Jih-Jung Chen +4 more
doaj +1 more source
Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies
CNS Neuroscience &Therapeutics, Volume 29, Issue 9, Page 2397-2412, September 2023., 2023 Abstract Depression is a common but severe mood disorder with a very high prevalence across the general population. Depression is of global concern and poses a threat to human physical and mental health. Ferulic acid (FA) is a natural active ingredient that has antioxidative, anti‐inflammatory, and free radical scavenging properties.
Xiaoyu Dong, Dongxue Zhao
wiley +1 more source
Computational and Mathematical Methods in Medicine, Volume 2023, Issue 1, 2023., 2023 Traditional Chinese medicine (TCM) prescriptions have made great contributions to the treatment of diseases and health preservation. To alleviate the shortage of TCM resources and improve the professionalism of automatically generated prescriptions, this paper deeply explores the connection between symptoms and herbs through deep learning technology ...
Jiaxin Hou +6 more
wiley +1 more source