Results 91 to 100 of about 692 (220)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Unraveling the Place of Small Molecules in the Treatment of Fistulizing Crohn's Disease-A Systematic Review and Network Meta-Analysis. [PDF]

Crohns Colitis 360, 2023
Attauabi M, Rasmussen DN, Bergenheim FO, Burisch J, Seidelin JB.   +4 more
europepmc   +1 more source

Larval Arctic cod (Boreogadus saida) exhibit stronger developmental and physiological responses to temperature than to elevated pCO2

Journal of Fish Biology, EarlyView.
Abstract High‐latitude ecosystems are simultaneously warming and acidifying under ongoing climate change. Arctic cod (Boreogadus saida) are a key species in the Arctic Ocean and have demonstrated sensitivity to ocean warming and acidification as adults and embryos, but their larval sensitivity to the combined stressors is unknown. In a laboratory multi‐
Emily Slesinger, Louise A. Copeman, Benjamin J. Laurel, Mary Beth R. Hicks, Paul J. Iseri, Michelle A. Stowell, Thomas P. Hurst   +6 more
wiley   +1 more source

Effect of denture cleansers and surface treatments on the color stability, gloss, and wettability of CAD‐CAM denture bases

Journal of Prosthodontics, EarlyView.
Abstract Purpose To evaluate the impact of surface treatments and chemical denture cleansers on the surface color stability, gloss, and wettability of compression‐molded, 3D‐printed, and milled denture base materials. Materials and Methods Specimens (12 × 16 × 7 mm) were fabricated from a standardized STL file in three denture base materials ...
Suonds Alareifi, Amal Alfaraj, Frank Lippert, Brenda Hanes, Chao‐Chieh Yang, Wei‐Shao Lin   +5 more
wiley   +1 more source

Synergistic Benefits of Butyric Acid and Resistant Potato Starch on Growth and Gut Health in Weaned Pigs

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Newly‐weaned piglets face challenges such as reduced feed intake, impaired gut function, and susceptibility to post‐weaning diarrhoea, increasing the need for dietary strategies that support gut health and growth. This study investigated the effects of dietary supplementation with butyric acid (BA), resistant potato starch (PS), and their ...
Kathryn Ruth Connolly, Torres Sweeney, John V. O'Doherty   +2 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response

Plant Biotechnology Journal, EarlyView.
ABSTRACT Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite its impact, research on E. necator pathogenicity and grapevine responses remains limited.
Bo Mu, Ruixin Tang, Zhaolin Teng, Jinfu Chen, Kaicheng Cui, Feng Wei, Wenxiang Kong, Shunyuan Xiao, Xiangnan Xu, Jia‐Yue Feng, Ying‐Qiang Wen   +10 more
wiley   +1 more source

Cinema novo

Ovaj diplomski rad bavi se filmskim pokretom Brazila Cinema Novo. Kroz njega ću pokušati prikazati njegovu važnost za razvoj filma u Brazilu, ali i promjene koje je potaknuo u brazilskom društvu. Izložit ću njegove najvažnije karakteristike, kao i probleme na koje su redatelji pokreta nailazili.
openaire   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source