Results 151 to 160 of about 6,120 (193)
Some of the next articles are maybe not open access.
Update on the ECG component of the CiPA initiative
Journal of Electrocardiology, 2018The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is validating a new paradigm for assessing proarrhythmic potential of drugs that goes beyond hERG block and QT prolongation. Based on in vitro data of the drug's effects on multiple cardiac ion channel currents, CiPA's in silico model of the human cardiomyocyte will classify drugs as low,
openaire +2 more sources
CIPA’s Perspectives on Cultural Heritage
2018Taking care of mankind’s cultural heritage is a well-established obligation to us and to our future generations. To that end numerous experts are contributing. Contemporary technological advances, i.e. digital achievements, have helped a lot to this end. In this paper these technological advances are briefly presented and explained.
openaire +2 more sources
1997
Abstract The dpA nucleotide sequence from E. coli (GenBank accession number M31045) predicts a protein of 758 amino acids, containing sequences that are highly conserved between CIpA, CIpB,, other HSP100 family members (Gottesman et al., 1990b, 1996; Squires, Squires, 1992; see also the overview of HSP100/Clp proteins, p. 231). The first
S Gottesman, S Wickner, M R Maurizi
openaire +1 more source
Abstract The dpA nucleotide sequence from E. coli (GenBank accession number M31045) predicts a protein of 758 amino acids, containing sequences that are highly conserved between CIpA, CIpB,, other HSP100 family members (Gottesman et al., 1990b, 1996; Squires, Squires, 1992; see also the overview of HSP100/Clp proteins, p. 231). The first
S Gottesman, S Wickner, M R Maurizi
openaire +1 more source
CipA and CipB as Scaffolds To Organize Proteins into Crystalline Inclusions
ACS Synthetic Biology, 2017Natural and synthetic scaffolds support enzyme organization in complexes, and they regulate their function and activity. Here we report that CipA and CipB, two small proteins that form protein crystalline inclusions (PCIs) in the cytoplasm of Photorhabdus luminescens, can be utilized as scaffolds to efficiently incorporate exogenous proteins into PCIs.
Yang Wang, Ralf Heermann, Kirsten Jung
openaire +2 more sources