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Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy

Autophagy, 2023
Circular RNAs (circRNAs) are special non-coding RNA (ncRNA) molecules that play a significant role in many diseases. However, the biogenesis and regulation of circRNAs in diabetic nephropathy (DN) are largely unknown. Here, we investigated the expression
Liu Xueqi   +11 more
semanticscholar   +1 more source

Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma.

Cancer Letters, 2023
Hepatocellular carcinoma (HCC) is often associated with poor outcomes due to lung metastasis. ICAM-1+ circulating tumor cells, termed circulating cancer stem cells (CCSCs), possess stem cell-like characteristics. However, it is still unexplored how their
Ruijiao Kong   +9 more
semanticscholar   +1 more source

CirC: Compiler infrastructure for proof systems, software verification, and more

IEEE Symposium on Security and Privacy, 2022
Cryptographic tools like proof systems, multi-party computation, and fully homomorphic encryption are usually applied to computations expressed as systems of arithmetic constraints.
Alex Ozdemir, Fraser Brown, R. Wahby
semanticscholar   +1 more source

To Circ or Not: A Reappraisal

Urologic Nursing, 2012
Routine circumcision remains a topic of controversy. The most recent male circumcision policy from the American Academy of Pediatrics argued that data were insufficient to recommend routine circumcision. Recent trials in Africa evaluating male circumcision for the prevention of sexually transmitted diseases have, however, revived the circumcision ...
Asma, Ahmed, Pamela, Ellsworth
openaire   +2 more sources

A Noncoding Regulatory RNAs Network Driven by Circ‐CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma

Hepatology, 2020
Hepatocellular carcinoma (HCC) is one of the fastest‐rising causes of cancer‐related death worldwide, but its deficiency of specific biomarkers and therapeutic targets in the early stages lead to severe inadequacy in the early diagnosis and treatment of ...
Yanping Wei   +19 more
semanticscholar   +1 more source

Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis.

Cancer Letters, 2019
The biological functions of circular RNAs (circRNAs) in gastric cancer (GC) remain largely unexplored. Here, we identified that circ-RanGAP1 was significantly upregulated in both GC tissues and exosomes from the plasma of GC patients.
Jun Lu   +12 more
semanticscholar   +1 more source

Exosome-Derived Circ-PVT1 Contributes to Cisplatin Resistance by Regulating Autophagy, Invasion, and Apoptosis Via miR-30a-5p/YAP1 Axis in Gastric Cancer Cells

Cancer Biotherapy and Radiopharmaceuticals, 2020
Background: Emerging studies manifested that exosomal RNAs had pivotal roles in human cancer therapies. This article aimed to research the regulatory mechanism of exosomal circRNA-plasmacytoma variant translocation 1 (circ-PVT1) in cisplatin (DDP ...
W. Yao, P. Guo, Q. Mu, Yuecheng Wang
semanticscholar   +1 more source

Exosomes from CD133+ cells carrying circ‐ABCC1 mediate cell stemness and metastasis in colorectal cancer

Journal of Cellular Biochemistry, 2020
Colorectal cancer (CRC), a fatal tumor, has been diagnosed as one of the most prevalent types of cancers globally, inducing multiple cancer‐linked deaths.
Hong Zhao, Shixia Chen, Q. Fu
semanticscholar   +1 more source

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