Results 171 to 180 of about 109,508 (306)

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Breastfeeding in term and preterm infants with and without growth restriction: A 50‐year analysis of incidence and duration

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of the present study was to analyze breastfeeding rates and duration in relation to preterm birth, fetal growth restriction, and demographics over five decades. Methods This retrospective cohort study included 1559 individuals (aged 4–52 years) and their parents from the University Medical Center Mainz, Germany.
Achim Fieß, Alica Hartmann, Eva Mildenberger, Julia Winter, Mareike Ernst, Jonas Tesarz, Michael S. Urschitz, Norbert Pfeiffer, Alexander K. Schuster, Sandra Gißler, Dirk Wackernagel   +10 more
wiley   +1 more source

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

School Climate and Sleep Duration Among Adolescents at the Intersection of Multiple Social Positions

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Recent studies have indicated that sleep is fundamental for adolescents' physical and mental health. Although it is known that context influences sleep, the impact of school climate on sleep duration remains understudied. Methods Using a large, diverse, population‐based sample of adolescents attending California high schools (N ...
André Gonzales Real, Brian T. Gillis, Marla E. Eisenberg, G. Nic Rider, Benjamin Parchem, Samantha E. Lawrence, Stephen T. Russell   +6 more
wiley   +1 more source

New insights into the skeletal muscle circadian clock in ruminants. [PDF]

J Anim Sci Biotechnol
Wang Q, Chen Y, Chen Y, Ling Y, Gao S, Zhang Z, Ren D.   +6 more
europepmc   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

The Evolutionary Flexibility of the Drosophila Circadian Clock: Network Constraints or Adaptive Freedom? [PDF]

Genome Biol Evol
Creasey LD, Petrov PB, Tauber E.
europepmc   +1 more source

Irregularity in Daily Activities Predicts Depression via Reduced Perceived Control: A Daily Diary Study

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objectives Disruptions in social rhythm—referring to irregularities in daily activities such as meals, work, and social interactions—have been associated with increased psychological distress, including depression. While circadian rhythm‐related factors (e.g., sleep quality) have been proposed as key mechanisms underlying this link, emerging ...
Jaeyeon Jang, Sunkyung Yoon
wiley   +1 more source