Results 181 to 190 of about 11,759,117 (298)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Accuracy and Reliability of Magnetic Resonance Imaging Measurement of Medial Femoral Condyle for Femoral Component Sizing in Oxford Unicompartmental Knee Arthroplasty. [PDF]

Arthroplast Today
Gromprasit A, Thremthakanpon W, Siripocaratana K, Wanitcharoenporn W, Jitprapaikulsarn S, Sutthapakti B, Laoruengthana A.   +6 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Monocular Structured-Light Sensing for 3D Metallic Hole Measurement. [PDF]

Sensors (Basel)
Lv Z, Chen L, Tian Y, Zhang X, Shao J, Liu Y, Lv X, Zhu J, Zhan Z, Zhao Y.   +9 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Clock drawing test strategies among older adults with and without cognitive impairment. [PDF]

Dement Neuropsychol
Spenciere B, Dos Santos LCM, Charchat-Fichman H.   +2 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effect of Single Session Solution Focused Circle Technique on Working Memory, Hope and Psychological Well-being Among Individuals with Depression: A Controlled Study. [PDF]

Ann Neurosci
Vats S, Pullat MM, Pundeer A, Srivastava A, Kumar K.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Large Language Models and Adverse Event Detection Within Immunotherapy Clinical Trials.

JAMA Netw Open
Elia MV, Friesner ID, Kwon D, Ni L, Sinha S, Ishiyama Y, Zack T, Bridge M, Fong L, Hong JC.   +9 more
europepmc   +1 more source