Results 21 to 30 of about 3,020,470 (372)
eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
Oncogene, 2022 Extrachromosomal circular DNA (eccDNA) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising star because of its ubiquitous existence in cancers and its crucial role in oncogene ...
Li Peng +4 more
semanticscholar +1 more source
Extrachromosomal circular DNA: Current status and future prospects
eLife, 2022 Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.
Yiheng Zhao +4 more
semanticscholar +1 more source
CIRCULAR DNA MOLECULES IN THE GENUS DROSOPHILA [PDF]
Genetics, 1972 ABSTRACT The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster.
Elizabeth C. Travaglini, Jack C. Schultz
openalex +4 more sources
In vitro amplification of whole large plasmids via transposon-mediated oriC insertion
BioTechniques, 2021 DNA amplification is a fundamental technique in molecular biology. The replication cycle reaction is a new method for amplification of large circular DNA having oriC sequences, which is a replication initiation site of the Escherichia coli chromosome. We
Seia Nara, Masayuki Su'etsugu
doaj +1 more source
Cyclocytidine hydrochloride inhibits the synthesis of relaxed circular DNA of hepatitis B virus [PDF]
PeerJ, 2022 Background Cyclocytidine hydrochloride (HCl) has been reported to inhibit DNA synthesis by affecting DNA polymerase. Here, we tested the antiviral effect of cyclocytidine on hepatitis B virus (HBV) DNA synthesis, which is reliant on DNA polymerase ...
Xue Wang +7 more
doaj +2 more sources
Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer
Molecular Cancer, 2021 Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous ...
X. Ling +8 more
semanticscholar +1 more source
Circular Dichroism of DNA [PDF]
European Journal of Biochemistry, 1970 The circular dichroism of sixteen DNA samples from fourteen species has been determined. Plots of molar ellipticity against base composition show considerable scatter, which is much too great to be accounted for in terms of reproducibility of materials and measurements.
L. Rowland Hill +2 more
openaire +3 more sources
Serious overestimation in quantitative PCR by circular (supercoiled) plasmid standard: microalgal pcna as the model gene. [PDF]
PLoS ONE, 2010 Quantitative real-time PCR (qPCR) has become a gold standard for the quantification of nucleic acids and microorganism abundances, in which plasmid DNA carrying the target genes are most commonly used as the standard.
Yubo Hou +3 more
doaj +1 more source
DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing
bioRxiv, 2023 Long single-molecular sequencing, such as PacBio circular consensus sequencing (CCS) and nanopore sequencing, is advantageous in detecting DNA 5-methylcytosine (5mC) in CpGs, especially in repetitive genomic regions.
Peng Ni +12 more
semanticscholar +1 more source
Nanoconfined Circular DNA [PDF]
Biophysical Journal, 2014 Nanofluidic channels have become a versatile tool to manipulate single DNA molecules. They allow investigation of confined single DNA molecules from a fundamental polymer physics perspective as wel ...
Mohammadreza Alizadehheidari +9 more
openaire +2 more sources