Results 31 to 40 of about 3,020,470 (372)

TeCD: The eccDNA Collection Database for extrachromosomal circular DNA

BMC Genomics, 2023
Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo, Ze Zhang, Qingcui Li, Xiao Chang, Xiaoping Liu   +4 more
doaj   +1 more source

Hepatitis B virus cccDNA is formed through distinct repair processes of each strand

Nature Communications, 2021
HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is
Lei Wei, Alexander Ploss
doaj   +1 more source

To Be or Not to Be: Circular RNAs or mRNAs From Circular DNAs? [PDF]

Frontiers in Genetics, 2019
In recent years, there has been a growing interest in circular RNAs (circRNAs) since they are involved in a wide spectrum of cellular functions that might have a large impact on phenotype and disease. CircRNAs are mainly recorded by RNA-Seq and computational methods focused on the detection of back-splicing junction sequences considered the diagnostic ...
Iparraguirre, Leire, Prada-Luengo, Iñigo, Regenberg, Birgitte, Otaegui, David   +3 more
openaire   +6 more sources

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance We observed the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. We found that the plasma eccDNA molecules were longer than their linear counterparts. Among such eccDNA molecules, those of fetal origin were
S. Sin, P. Jiang, J. Deng, Lu Ji, S. Cheng, Anindya Dutta, T. Leung, K. C. Chan, R. Chiu, Y. Lo   +9 more
semanticscholar   +1 more source

DNA-like Helices as Nanosized Polarizers of Electromagnetic Waves

Frontiers in Nanotechnology, 2022
The possibility of using a conducting double DNA-like helix as the basis of an electromagnetic wave polarizer, which converts an incident linearly polarized wave into a reflected wave with circular polarization, has been shown. A high-frequency resonance
Igor V. Semchenko, Ivan S. Mikhalka, Sergei A. Khakhomov, Andrey L. Samofalov, Aliaksei P. Balmakou   +4 more
doaj   +1 more source

Circular DNA's from HeLa cell nuclei and mitochondria [PDF]

, 1970
An electron microscopic observation was made on the DNA's extracted from purified HeLa cell nuclei, mitochondria, and the whole cell, and fractionated by ethidium bromide-cesium chloride density gradient method or sucrose density gradient method. Nuclear
Hirata, Seiichi, Nishida, Shigeru, Oda, Takuzo, Omura, Sachiko, Yamamoto, Shinichiro   +4 more
core   +1 more source

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Science Advances, 2020
EccDNAs are hiding in plain sight in conventional ATAC-seq data. Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells.
Pankaj Kumar, Shashi Kiran, S. Saha, Zhangli Su, Teressa Paulsen, Ajay Chatrath, Y. Shibata, Etsuko Shibata, A. Dutta   +8 more
semanticscholar   +1 more source

Condensation of circular DNA [PDF]

The Journal of Chemical Physics, 2013
A simple model of a circularly closed double-stranded DNA in a poor solvent is considered as an example of a semi-flexible polymer with self-attraction. To find the ground states, the conformational energy is computed as a sum of the bending and torsional elastic components and the effective self-attraction energy.
openaire   +4 more sources

Mitochondrial DNA from hamster tumors induced by adenovirus type 12 [PDF]

, 1970
1. Mitochondria isolated from hamster tumors induced by adenovirus type 12 possessed circular DNA fibers. 2. The mean value of the length of the highest frequency group of the circular DNA molecules was 4.92 ±0.38 μ. 3. Catenated dimer DNA molecules
Nishida, Shigeru, Oda, Takuzo
core   +1 more source

Characterization of the DNA binding activity of structural protein VP1 from chicken anaemia virus

BMC Veterinary Research, 2018
Background Chicken anaemia virus (CAV) is commonly found in poultry. VP1 is the sole structural protein of CAV, which is the major component responsible for capsid assembly. The CAV virion consists of the VP1 protein and a viral genome. However, there is
Guan-Hua Lai, Ming-Kuem Lin, Yi-Yang Lien, Jai-Hong Cheng, Fang-Chun Sun, Meng-Shiunn Lee, Hsi-Jien Chen, Meng-Shiou Lee   +7 more
doaj   +1 more source