Results 41 to 50 of about 208,265 (305)
Life, 2018 Propagation of genetic information is a fundamental prerequisite for living cells. We recently developed the replication cycle reaction (RCR), an in vitro reaction for circular DNA propagation, by reconstitution of the replication cycle of the ...
Tomonori Hasebe +3 more
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New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation
Cells, 2020 The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
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Condensation of circular DNA [PDF]
The Journal of Chemical Physics, 2013 A simple model of a circularly closed double-stranded DNA in a poor solvent is considered as an example of a semi-flexible polymer with self-attraction. To find the ground states, the conformational energy is computed as a sum of the bending and torsional elastic components and the effective self-attraction energy.
openaire +3 more sources
Data in Brief, 2018 The data presented in this article are related to the research article entitled ''Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes'' Zhang et al. (in press) [1].
Hao Zhang, Tianhu Li
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BMC Bioinformatics, 2019 Background Circular DNA has recently been identified across different species including human normal and cancerous tissue, but short-read mappers are unable to align many of the reads crossing circle junctions hence limiting their detection from short ...
Iñigo Prada-Luengo +3 more
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A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement
AIP Advances, 2013 We report strong evidence for a localized transition in the size variation of circular DNA between strong and moderate regimes of slitlike confinement. A novel and rigorous statistical analysis was applied to our recent experimental measurements of DNA ...
Elizabeth A. Strychalski +2 more
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The Knot Spectrum of Confined Random Equilateral Polygons
Computational and Mathematical Biophysics, 2014 It is well known that genomic materials (long DNA chains) of living organisms are often packed compactly under extreme confining conditions using macromolecular self-assembly processes but the general DNA packing mechanism remains an unsolved problem. It
Diao Y. +4 more
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Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Aim. Evaluate significance of covalently closed circular DNA of hepatitis В virus as a marker for detection of occult viral hepatitis В in Uzbekistan population with hepatitis of various genesis. Materials and methods.
A. V. Semenov +6 more
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Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.
PLoS ONE, 2019 Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and ...
Fumihiko Takeuchi +16 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell +14 more
wiley +1 more source