Results 231 to 240 of about 297,585 (294)

Uncovering the new landscape of leukoaraiosis through the circular RNA-miRNA-mRNA axis. [PDF]

Front Neurol
Zhu C, Chang C, Jin Q, Xu X, Pang W, Fang Y, Yang T, Jin L, Wang D.   +8 more
europepmc   +1 more source

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Circular RNA hsa-circ-0001030 suppresses proliferation and cisplatin tolerance in TSCC via interaction with PKM2. [PDF]

Cancer Drug Resist
Yang H, Yan Y, Tan Z, Xu X, Chen K, Li Q, Liufu N, Ji F.   +7 more
europepmc   +1 more source

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

PTBP1-mediated inhibition of circular RNA SCMH1 biogenesis impairs brain recovery after ischemic stroke. [PDF]

Theranostics
Bai Y, Han B, Zhang Y, Wen L, Liu C, Wang Y, Cui J, Zheng B, Cai N, Xu L, Shen L, Zhang Y, Yao H.   +12 more
europepmc   +1 more source

Harnessing the Loop: The Perspective of Circular RNA in Modern Therapeutics. [PDF]

Vaccines (Basel)
Zhao YY, Zhu FM, Zhang YJ, Wei HY.
europepmc   +1 more source

Circular RNA <i>circHomer1</i> mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. [PDF]

Sci Adv
Cai Y, Zheng Z, Xu H, Zhu Y, Zepeda JC, Grueter BA, Wang X, Ku T, Duan Y, Tsang HWS, Fu WY, Fu AKY, Mellios N, Wong HH, Lai KO, Ip JPK.   +15 more
europepmc   +1 more source

Circular RNA lipid nanoparticle vaccine against SARS-CoV-2. [PDF]

Proc Natl Acad Sci U S A
Swingle KL, Hamilton AG, Han X, Liao KC, Safford HC, Thatte AS, Geisler HC, Xu J, Saw TY, Wan Y, Mitchell MJ.   +10 more
europepmc   +1 more source

Circular RNA role in Atherosclerosis Development and Progression. [PDF]

Curr Atheroscler Rep
Greco S, Gaetano C, Mazzaccaro D, Martelli F.   +3 more
europepmc   +1 more source