Results 291 to 300 of about 1,797,821 (330)

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling. [PDF]

Cell Death Discov
Yang X, Liu L, Yu Z, Chen Y, Xu S, Liu M, Wang M, Guo H, Zhang Z, Shan B, Cai S, Pan M, Zhang J, Wang F, Zheng Y.   +14 more
europepmc   +1 more source

Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti‐Inflammatory Treatment Efficacy in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
Triblock copolymer‐reinforced liposomal mimics of extracellular vesicles are engineered with tunable membrane elasticity. A semi‐elastic formulation (Tri‐ARTEX8:2) co‐encapsulating stem cell cytosolic extract and AntagomiR155 targets inflamed joints via the ELVIS effect, reprograms macrophages from M1 to M2, and markedly alleviates collagen‐induced ...
Dahwun Kim, Hwira Baek, Su Yeon Lim, Min Sang Lee, Siyan Lyu, Jihyun Lee, Tun Naw Sut, Marta Gonçalves, Jeong Yi Kang, Joshua A. Jackman, Jin Woong Kim, Ji Hoon Jeong   +11 more
wiley   +1 more source

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling. [PDF]

Invest Ophthalmol Vis Sci
Lu S, Liu Q, Ye F, Zhang Z, Shi L, Li X, Mu W, Jiang Q, Yan B.   +8 more
europepmc   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

Rational Design and Immunological Mechanisms of Circular RNA-Based Vaccines: Emerging Frontiers in Combating Pathogen Infection. [PDF]

Vaccines (Basel)
Zhang Y, Jin S, Zuo Z, Liu S, Xu J, Yang C, Wan P, Xun L, Luo M, Yang F, Chen W, Song Z, Qi J.   +12 more
europepmc   +1 more source

Discovery of a novel viroid-like circular RNA in colorectal cancer. [PDF]

Cancer Commun (Lond)
Wu M, Li W, Hu N, Liu C, Li J, Li Y, Xu N, Shi J, Sun J, Li J, Hu Y.   +10 more
europepmc   +1 more source

Circular RNA, A Molecule with Potential Chemistry and Applications in RNA-based Cancer Therapeutics: An Insight into Recent Advances. [PDF]

Top Curr Chem (Cham)
Shafaghat Z, Radmehr S, Saharkhiz S, Khosrozadeh A, Feiz K, Alkhathami AG, Taheripak G, Ramezani Farani M, Rahmati R, Zarimeidani F, Bassereh H, Bakhtiyari S, Alipourfard I.   +12 more
europepmc   +1 more source