Results 101 to 110 of about 99,064 (327)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Impellent impeller—Switching intra‐aortic balloon pump to IMPELLA‐CP after ST‐segment elevation myocardial infarction and refractory cardiogenic shock

Clinical Case Reports, 2019
Cardiogenic shock is a dreadful complication of myocardial infarction. Despite widespread use and availability, intra‐aortic balloon pump (IABP) does not reduce mortality nor improves outcomes.
Marco Contarini, Francesco Costa, Maria Victoria Garcia Ruiz, Renato F. M. Scalise, Giovanni De Velli, Paola Murè, Paolo Mazzone, Giorgio Sacchetta, Giuseppe Andò   +8 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Circulatory collapse requiring mechanical circulatory support in a child with autoimmune adrenal insufficiency: a case report

BMC Pediatrics
Background We report a rare case of new onset autoimmune adrenal insufficiency in childhood, presenting with severe shock requiring mechanical circulatory support.
Yahia Hejazi, Ken Tegtmeyer, Meghan Chlebowski, Katja M. Gist   +3 more
doaj   +1 more source

Outcomes of following transcatheter and surgical interventions in patients with acute valvular dysfunction with cardiogenic shockCentral MessagePerspective

JTCVS Open
Objectives: Although surgery remains the gold standard treatment for acute valvular dysfunction complicated by cardiogenic shock, transcatheter management has emerged as an alternative.
Yu Hohri, MD, PhD, Erfan Faridmoayer, MD, Yanling Zhao, MS, MPH, Paul Kurlansky, MD, Krushang Patel, MD, Morgan Moroi, MD, Christine Yang, BS, Giovanni Ferrari, PhD, Isaac George, MD, Hiroo Takayama, MD, PhD, Koji Takeda, MD, PhD   +10 more
doaj   +1 more source

Racial Disparities in the Utilization and Outcomes of Temporary Mechanical Circulatory Support for Acute Myocardial Infarction-Cardiogenic Shock [PDF]

, 2021
Rahul Vojjini, Sri Harsha Patlolla, Wisit Cheungpasitporn, Arnav Kumar, Pranathi R. Sundaragiri, Rajkumar Doshi, Allan S. Jaffe, Gregory W. Barsness, David R. Holmes, S. Tanveer Rab, Saraschandra Vallabhajosyula   +10 more
openalex   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

The utility of monitoring end-tidal carbon dioxide in emergency department to predict inhospital mortality of patients presenting with nontraumatic shock: A prospective observational study

Turkish Journal of Emergency Medicine
OBJECTIVES: We aimed to identify the ability of end-tidal carbon dioxide (EtCO2) to predict inhospital mortality of patients presenting to the emergency department (ED) with nontraumatic circulatory shock.
R Abhiraj, Meera Ekka, Aravind Sreekumar, Praveen Aggarwal, Nayer Jamshed, Sanjeev Kumar Bhoi, Maroof Ahmed Khan   +6 more
doaj   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Distributive shock in cardiac intensive care unit patients

Indian Heart Journal
Shock is a life-threatening condition of circulatory failure. Mixed shock is observed in approximately 24.5 % of patients with cardiogenic shock.
Sarvesh Pal Singh
doaj   +1 more source