Results 111 to 120 of about 99,064 (327)

Adrenal Crisis [PDF]

open access: yes, 2019
Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients.
Falhammar, Henrik   +2 more
core   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

open access: yesAdvanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li   +9 more
wiley   +1 more source

Hemodynamic Support in Cardiogenic Shock in the Cardiac Catheterization Laboratory

open access: yesEmergency Care and Medicine
Cardiogenic shock is a life-threatening, time-sensitive syndrome characterized by clinical and biochemical tissue hypoperfusion caused by circulatory failure secondary to inadequate cardiac output.
Cesar Jiménez-Méndez   +6 more
doaj   +1 more source

Stress Cardiomyopathy Managed with Extracorporeal Support after Self-Injection of Epinephrine

open access: yesCase Reports in Critical Care, 2017
A 28-year-old man was admitted to the ICU for self-injection of Epinephrine. This injection resulted in the rapid development of a catecholamine-induced cardiomyopathy (inverted Takotsubo) with a severe cardiogenic shock.
Bourenne Jeremy   +4 more
doaj   +1 more source

Mathematical analysis of blood flow model through channels with flexible walls [PDF]

open access: yes, 2011
A simplified mathematical model of blood flow through flexible arteries is developed and analyzed. The resulting system of non-linear, non-homogeneous PDE\u27s is analyzed numerically using the Richtmyer Lax-Wendroff method.
Bozzuto, Lisa A
core   +2 more sources

Extracorporeal membrane oxygenation via sternotomy for circulatory shock [PDF]

open access: bronze, 2008
Stephen Horton   +6 more
openalex   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy   +16 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak   +9 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

open access: yesAdvanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang   +21 more
wiley   +1 more source

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