Results 141 to 150 of about 99,064 (327)

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Risk Factors and Neurological Outcomes Associated With Circulatory Shock After Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study. [PDF]

Neurosurgery, 2022
Toro C, Hatfield J, Temkin N, Barber J, Manley G, Ohnuma T, Komisarow J, Foreman B, Korley FK, Vavilala MS, Laskowitz DT, Mathew JP, Hernandez A, Sampson J, James ML, Raghunathan K, Goldstein BA, Markowitz AJ, Krishnamoorthy V, TRACK-TBI Investigators.   +19 more
europepmc   +1 more source

Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study [PDF]

, 2020
Fernando Luís Scolari, Daniel Schneider, Débora Vacaro Fogazzi, Miguel Gus, Marciane Maria Rover, Marcely Gimenes Bonatto, Gustavo Neves de Araújo, André Zimerman, Daniel Sganzerla, Lívia Adams Goldraich, Cassiano Teixeira, Gilberto Friedman, Carísi Anne Polanczyk, Luís Eduardo Paim Rohde, Régis Goulart Rosa, Rodrigo Vugman Wainstein   +15 more
openalex   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Using web-based reflection with video to enhance high fidelity undergraduate nursing clinical skills education

, 2010
The United States is currently facing a crisis in health care and health professions education. Various studies (Committee on Quality of Health Care in America 2000; 2001; General Accounting Office, 2001) have documented astonishing death rates from ...
Loving, G, McPherson, MA, Shortridge, A
core  

Mechanical Circulatory Support Strategies in Takotsubo Syndrome with Cardiogenic Shock: A Systematic Review [PDF]

Johanna K. R. von Mackensen, Vanessa I. T. Zwaans, Ahmed El Shazly, Karel M. Van Praet, Roland Heck, Christoph Starck, Felix Schoenrath, Evgenij Potapov, Jörg Kempfert, Stephan Jacobs, Volkmar Falk, Leonhard Wert   +11 more
openalex   +1 more source

Exploring circulatory shock and mortality in viper envenomation: a prospective observational study from India [PDF]

, 2018
Maya Gopalakrishnan, K. V. Vinod, Tarun Kumar Dutta, Kusa Kumar Shaha, M. G. Sridhar, Suman Saurabh   +5 more
openalex   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Determinants of venous return in steady-state physiology and asphyxia-induced circulatory shock and arrest: an experimental study. [PDF]

Intensive Care Med Exp, 2022
Chalkias A, Laou E, Papagiannakis N, Varvarousi G, Ragias D, Koutsovasilis A, Makris D, Varvarousis D, Iacovidou N, Pantazopoulos I, Xanthos T.   +10 more
europepmc   +1 more source