Results 41 to 50 of about 99,064 (327)

Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. [PDF]

, 2014
At least a third of the blood supply in the world is used to transfuse 1-2 units of packed red blood cells for each intervention and most clinical trials of blood substitutes have been carried out at this level of oxygen carrying capacity (OCC ...
Acharya, Seetharama A, Cabrales, Pedro, Intaglietta, Marcos, Kistler, Erik B, Salazar Vázquez, Beatriz Y, Subramaniam, Shankar, Tartakovsky, Daniel M, Tsai, Amy G   +7 more
core   +3 more sources

Microcirculation vs. Mitochondria—What to Target?

Frontiers in Medicine, 2020
Circulatory shock is associated with marked disturbances of the macro- and microcirculation and flow heterogeneities. Furthermore, a lack of tissue adenosine trisphosphate (ATP) and mitochondrial dysfunction are directly associated with organ failure and
Tamara Merz, Nicole Denoix, Markus Huber-Lang, Mervyn Singer, Peter Radermacher, Oscar McCook   +5 more
doaj   +1 more source

Skin microcirculatory reactivity assessed using a thermal challenge is decreased in patients with circulatory shock and associated with outcome

Annals of Intensive Care, 2018
Background Shock states are characterized by impaired tissue perfusion and microcirculatory alterations, which are directly related to outcome. Skin perfusion can be noninvasively evaluated using skin laser Doppler (SLD), which, when coupled with a local
Diego Orbegozo, Wasineenart Mongkolpun, Gianni Stringari, Nikolaos Markou, Jacques Creteur, Jean-Louis Vincent, Daniel De Backer   +6 more
doaj   +1 more source

Ventricular assist device implantation in the elderly [PDF]

, 2014
BACKGROUND: Dramatic advances in ventricular assist device (VAD) design and patient management have made mechanical circulatory support an attractive therapeutic option for the growing pool of elderly heart failure patients.
Boyd, Jack H., Hiesinger, William, Woo, Y. Joseph   +2 more
core   +1 more source

The failing heart under stress: echocardiography is an essential monitoring tool in the Intensive Care Unit [PDF]

, 2006
A
Poelaert, Jan
core   +2 more sources

Acute coronary syndrome associated cardiogenic shock in the catheterization laboratory: peripheral veno-arterial extracorporeal membrane oxygenator management and recommendations

Frontiers in Medicine, 2023
Cardiogenic shock (CS) in acute coronary syndrome (ACS) is a critical disease with high mortality rates requiring complex treatment to maximize patient survival chances.
Réka Ehrenberger, Balázs T. Németh, Péter Kulyassa, Gábor A. Fülöp, Dávid Becker, Boldizsár Kiss, Endre Zima, Béla Merkely, István F. Édes   +8 more
doaj   +1 more source

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]

, 2005
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson, Annane, Astudillo, Barie, Barie, Bastos, Bertsch, Blomquist, Bollaert, Bolton, Bolton, Bone, Briegel, Briegel, Briegel, Briegel, Danielson, Donato, Eidelman, Endo, Haimoto, Herrmann, Hollenberg, Hund, Hund, Jonsson, Keh, Lindner, Marshall, Metinko, Munck, Mussack, Mussack, Pelinka, Pelinka, Rosen, Schwarz, Stanimirovic, Usui, Vincent, Waage, Weiss, Westaby, Wheeler, Wiesmann, Wunderlich, Young   +46 more
core   +2 more sources

Implications of Myocardial Infarction on Management and Outcome in Cardiogenic Shock

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The randomized DOREMI (Dobutamine Compared to Milrinone) clinical trial evaluated the efficacy and safety of milrinone and dobutamine in patients with cardiogenic shock. Whether the results remain consistent when stratified by acute myocardial
Richard G. Jung, Pietro Di Santo, Rebecca Mathew, Omar Abdel‐Razek, Simon Parlow, Trevor Simard, Jeffrey A. Marbach, Taylor Gillmore, Brennan Mao, Jordan Bernick, Pascal Theriault‐Lauzier, Angel Fu, Lawrence Lau, Pouya Motazedian, Juan J. Russo, Marino Labinaz, Benjamin Hibbert   +16 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source