Results 101 to 110 of about 680,529 (391)

Risk Prediction Models for Post‐Operative Mortality in Patients With Cirrhosis

Hepatology, 2020
Patients with cirrhosis are at increased risk of postoperative mortality. Currently available tools to predict postoperative risk are suboptimally calibrated and do not account for surgery type.
N. Mahmud, Zachary P Fricker, R. Hubbard, G. Ioannou, J. Lewis, T. Taddei, K. Rothstein, M. Serper, D. Goldberg, D. Kaplan   +9 more
semanticscholar   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

Advanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding   +9 more
wiley   +1 more source

Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up [PDF]

, 2000
Background/Aims: Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, few data exist on the long-term ...
Beuers, Ulrich, Gerbes, Alexander L., Haller, Matthias, Krämling, Hans-Jörg, Pape, Gerd R., Paumgartner, Gustav, Rau, Horst, Rust, Christian, Schildberg, Friedrich Wilhelm   +8 more
core   +2 more sources

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

International Journal of Molecular Sciences, 2019
Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC despite recent progress in the efficacy of anticancer drugs for advanced ...
T. Kanda, T. Goto, Y. Hirotsu, M. Moriyama, M. Omata   +4 more
semanticscholar   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Liver transplantation for viral hepatitis in 2015 [PDF]

, 2016
Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease and for patients with liver cell cancer related to liver disease.
Bortoluzzi, Ilaria, Burra, Patrizia, Ferrarese, Alberto, Gambato, Martina, Germani, Giacomo, Nadal, Elena, Russo, FRANCESCO PAOLO, Senzolo, Marco, Zanetto, Alberto   +8 more
core   +1 more source

Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications.

Gastroenterology, 2017
BACKGROUND & AIMS We performed a prospective study to investigate the effects of a sustained viral response (SVR) on outcomes of patients with hepatitis C virus (HCV) infection and compensated cirrhosis.
P. Nahon, Valérie Bourcier, Richard Layese, E. Audureau, C. Cagnot, P. Marcellin, D. Guyader, H. Fontaine, D. Larrey, V. de Lédinghen, D. Ouzan, F. Zoulim, D. Roulot, A. Tran, J. Bronowicki, J. Zarski, V. Leroy, G. Riachi, P. Calès, J. Péron, L. Alric, M. Bourlière, P. Mathurin, S. Dharancy, J. Blanc, A. Abergel, L. Serfaty, A. Mallat, J. Grangé, P. Attali, Y. Bacq, C. Wartelle, T. Dao, Y. Benhamou, C. Pilette, C. Silvain, C. Christidis, D. Capron, B. Bernard-Chabert, D. Zucman, V. Di Martino, V. Thibaut, D. Salmon, M. Ziol, A. Sutton, S. Pol, F. Roudot-thoraval   +46 more
semanticscholar   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

BMC Medicine, 2019
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC).
M. Alexander, A. K. Loomis, J. van der Lei, T. Duarte-Salles, D. Prieto-Alhambra, D. Ansell, A. Pasqua, F. Lapi, P. Rijnbeek, M. Mosseveld, Dawn Waterworth, Stuart Kendrick, N. Sattar, W. Alazawi   +13 more
semanticscholar   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source