Results 111 to 120 of about 419,003 (365)

Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis [PDF]

, 1991
In 11 patients with decompensated cirrhosis and deteriorating renal function, the effect of the vasoconstrictor substance 8-ornithin vasopressin (ornipressin; POR 8; Sandoz, Basel, Switzerland) on renal function, hemodynamic parameters, and humoral ...
Alexander L. Gerbes, Anton Laggner, Arendt, Barratt-Boyes, Barry, Bauch, Brenner, Bruno Schneeweiss, Burnett, Cohn, Davies, Epstein, Epstein, Epstein, Fernandez-Seara, Fischer, Fried, Fyrquist, Ganger, Ganong, Georg Grimm, Gerbes, Gerbes, Gerbes, Gerbes, Gornel, Granger, Haber, Harald Reither, Heide Hörtnagl, Heinrich, Heyndrickx, Hintze, Holtz, Hörtnagl, Katsube, Kew, Klepetko, Koepke, Kontos, Kotelanski, Kurt Lenz, Lancestremere, Lenz, Lenz, Lenz, López, Manning, Marin-Grez, Murray, Needleman, Nicholls, Oshima, Panos, Petrillo, Rainer Schmid, Richards, Salerno, Salerno, Schenker, Schmid, Schrier, Shapiro, Siegel, Solis-Herruzo, Wernze, Wilfred Druml   +66 more
core   +1 more source

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

Advanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li, Tongwei Zhang, Tongxiang Tao, Yaxuan Liu, Haining Xia, Sajid ur Rehman, Zeyong Guo, Jing Zhang, Ruiguo Chen, Zhan Zhang, Junfeng Wang, Kun Ma   +11 more
wiley   +1 more source

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

Nature Communications, 2019
The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis ...
C. Caussy, A. Tripathi, G. Humphrey, Shirin Bassirian, Seema Singh, Claire S. Faulkner, R. Bettencourt, E. Rizo, L. Richards, Z. Xu, M. Downes, R. Evans, D. Brenner, C. Sirlin, R. Knight, R. Loomba   +15 more
semanticscholar   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

Hyponatremia in cirrhosis [PDF]

Journal of Hospital Medicine, 2012
AbstractHyponatremia is common in patients with cirrhosis. Portal hypertension, diuretics, large volume paracentesis without albumin, infection, and multiple medications are connected with the development or worsening of hyponatremia. Hyponatremia in cirrhosis, particularly advanced cirrhosis, is a common development.1 In a population survey of 997 ...
openaire   +3 more sources

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source

A Circulating Biomarker-based Framework for Diagnosis of Hepatocellular Carcinoma in a Clinically Relevant Model of Non-alcoholic Steatohepatitis; An OAD to NASH [PDF]

arXiv, 2017
Although cirrhosis is a key risk factor for the development of hepatocellular carcinoma (HCC), mounting evidence indicates that in a subset of patients presenting with non-alcoholic steatohepatitis (NASH), HCC manifests in the absence of cirrhosis. Given the sheer size of the non-alcoholic fatty liver disease (NAFLD) epidemic, and the dismal prognosis ...
arxiv  

Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications.

Gastroenterology, 2017
BACKGROUND & AIMS We performed a prospective study to investigate the effects of a sustained viral response (SVR) on outcomes of patients with hepatitis C virus (HCV) infection and compensated cirrhosis.
P. Nahon, Valérie Bourcier, Richard Layese, E. Audureau, C. Cagnot, P. Marcellin, D. Guyader, H. Fontaine, D. Larrey, V. de Lédinghen, D. Ouzan, F. Zoulim, D. Roulot, A. Tran, J. Bronowicki, J. Zarski, V. Leroy, G. Riachi, P. Calès, J. Péron, L. Alric, M. Bourliere, P. Mathurin, S. Dharancy, J. Blanc, A. Abergel, L. Serfaty, A. Mallat, J. Grangé, P. Attali, Y. Bacq, C. Wartelle, T. Dao, Y. Benhamou, C. Pilette, C. Silvain, C. Christidis, D. Capron, B. Bernard-Chabert, D. Zucman, V. Di Martino, V. Thibaut, D. Salmon, M. Ziol, A. Sutton, S. Pol, F. Roudot-thoraval   +46 more
semanticscholar   +1 more source

Drug interaction study in hospitalized hepatic cirrhosis patient in Dr.Ramelan navy hospital [PDF]

, 2009
Cirrhotic liver lead to some changes in pathophysiology such as reduction in liver blood flow, decrease some metabolic and synthetic function of the liver. Also there is a change in endothelial lining from hepatic sinusoid.
., Widyati, Bagijo, Hary, Hubeis, A. Aziz., Lorensia, Amelia   +3 more
core  

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source