Results 111 to 120 of about 680,529 (391)
TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis
Stem Cells International, 2016 Transforming growth factor-beta 1 (TGF-β1) plays a central role in hepatic progenitor cells- (HPCs-) mediated liver repair and fibrosis. However, different effects of TGF-β1 on progenitor cells have not been described.
Ai-Ting Yang +9 more
doaj +1 more source
Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease [PDF]
, 2015 Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse
Farinati, Fabio +5 more
core +1 more source
Gastroenterology, 2020 BACKGROUND & AIMS Cirrhosis is associated with changes in gut microbiome composition. Although ACLF is the most severe clinical stage of cirrhosis, there is lack of information about gut microbiome alterations in ACLF using quantitative metagenomics.
C. Solé +22 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai +6 more
wiley +1 more source
JHEP Reports, 2022 Background & Aims: Acute-on-chronic liver failure (ACLF) is a syndrome associated with organ failure and high short-term mortality. Recently, the role of surgery as a precipitating event for ACLF has been characterised.
Johannes Chang +12 more
doaj
Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease [PDF]
, 2013 Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as ...
Barclay, Stephen +7 more
core +2 more sources
Advanced Science, EarlyView.This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang +17 more
wiley +1 more source
Value of Ascitic Lipids in the Differentiation between Cirrhotic and Malignant Ascites [PDF]
, 1986 Ascitic fluid concentrations of cholesterol, triglycerides and phospholipids, were compared with ascitic fluid total protein in 40 patients with chronic liver disease, 51patients with various neoplasms and 1 patient with cardiac failure.
Alexander L. Gerbes +22 more
core +1 more source
Alcohol Consumption and Risk of Liver Cirrhosis: A Systematic Review and Meta-Analysis.
American Journal of Gastroenterology, 2019 OBJECTIVES To systematically summarize the risk relationship between different levels of alcohol consumption and incidence of liver cirrhosis. METHODS MEDLINE and Embase were searched up to March 6, 2019, to identify case-control and cohort studies ...
M. Roerecke +7 more
semanticscholar +1 more source
World Journal of Gastroenterology, 2014 Cirrhosis patients' comorbidities are their other diseases than cirrhosis. Comorbidities are neither causes nor consequences of cirrhosis, but they can increase mortality and are therefore clinically important. They are also an important source of confounding in epidemiologic studies.
openaire +2 more sources