Results 221 to 230 of about 691,603 (403)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

A Case of Congenital Cirrhosis of the Liver with Renal Tubular Defects Akin to Those in the Fanconi Syndrome [PDF]

, 1956
Michael Baber
openalex   +1 more source

Myocardial infarct-sparing effect of ischemic preconditioning abrogated in cirrhotic rat through involvement of mitochondrial permeability transition pore [PDF]

, 2012
Despite all studies undertaken mechanism of cirrhotic cardiomyopathy the role of cirrhosis on ischemia-reperfusion (I/R) injury and ischemic preconditioning (IPC) phenomenon hasn't been explored yet.
Dehpour, A.R., Jafrazedeh, F., Khori, V., Mohimani, H.R., Mohsen, N.   +4 more
core  

Phenotype characterization of heart failure with preserved ejection fraction in medical device and surgical trials

ESC Heart Failure, EarlyView.
This systematic review identified 24 clinical trials of medical device and surgical interventions for HFpEF, with 16 demonstrating at least safety and feasibility, but little evidence of long‐term benefit. Phenotype‐based responses suggest that certain interventions may benefit specific HFpEF subgroups, yet most trials suffered from heterogeneous ...
Kurdo Araz, Francesco Fioretti, Sara Ladak, Mohammed Obaidan, Javed Butler, Aamir Hameed   +5 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

URINARY EXCRETION OF AMINO ACIDS IN PATIENTS WITH CIRRHOSIS OF THE LIVER AND IN NORMAL ADULTS 12 [PDF]

, 1952
George J. Gabuzda, Richard D. Eckhardt, Charles S. Davidson   +2 more
openalex   +1 more source

Dynamics of urinary chloride and sodium and their link to decongestion in acute heart failure and preserved ejection fraction: NACLOCRo‐HF study

ESC Heart Failure, EarlyView.
The study evaluated urinary chloride (uCl) and sodium (uNa) trajectories in 70 elderly patients hospitalized with acute heart failure and preserved ejection fraction (HFpEF). Urine samples were collected at baseline, 24, 48 and 72 h. A multiparametric approach assessed decongestion using the clinical congestion score (CCS), portal vein (PV) pulsatility
Jorge Campos, Pau Llàcer, François Croset, Marina García, Carlos Pérez, Alberto Pérez, Marina Vergara, Paul Cevallos, Martín Fabregate, Cristina Fernández, Raúl Ruiz, Daniel Useros, Miriam Menacho, Miriam Domínguez, Esteban Pérez, Julio Núñez, Luis Manzano   +16 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Remarks ON THE OPERATIVE CURE OF ASCITES DUE TO LIVER CIRRHOSIS [PDF]

, 1912
Rutherford Morison
openalex   +1 more source

Liver stiffness measurement for non‐invasive assessment of central venous pressure in patients with heart failure: A multicentre pilot study

European Journal of Heart Failure, EarlyView.
Liver stiffness measurement for central venous pressure assessment. AUC, area under the curve; BMI, body mass index; CI, confidence interval; CVP, central venous pressure; HF, heart failure; LSM, liver stiffness measurement; LVEF, left ventricular ejection fraction. Abstract Aims Central venous pressure (CVP) is an important variable in assessing heart
Nicolas Girerd, Jan Biegus, Adam Janas, Piotr Buszman, Marcin Suska, Ovidiu Chioncel, Julie Foucquier, Anne Llorca, Laura Cantu Sanchez, Marat Fudim, Kevin Damman, Maria Rosa Costanzo, Beth Davison, Gad Cotter, Laurent Sandrin, Victor de Lédinghen, Alexandre Mebazaa   +16 more
wiley   +1 more source